Pilot Awardee #1: Macedo, Etienne, MD, PhD Title: Tubular Health Characterization in Acute Kidney Injury Despite improvement in AKI classification systems for AKI, timely diagnosis and assessment of AKI severity remains challenging. Renal tubule cells perform many of the essential kidney functions, including reabsorption, electrolyte transport, secretion of endogenous molecules and medications, acid/base balance control, and concentration and dilution of urine. Although well recognized as part of kidney health, these components of tubular function are not systematically captured for overall kidney evaluation in AKI. Recent advances in urinary and serum biomarkers of kidney damage have provided new tools to identify tubular injury that can be mapped to specific sites; however, these injury markers have not been correlated with alterations in tubular function. The combination of tubular function assessment in conjunction with kidney injury, glomerular filtration and permeability markers would provide a more accurate

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK079337-11
Application #
9592095
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2018-08-01
Budget End
2019-07-31
Support Year
11
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Type
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
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