Abstract

Pilot Awardee #1: Macedo, Etienne, MD, PhD Title: Tubular Health Characterization in Acute Kidney Injury Despite improvement in AKI classification systems for AKI, timely diagnosis and assessment of AKI severity remains challenging. Renal tubule cells perform many of the essential kidney functions, including reabsorption, electrolyte transport, secretion of endogenous molecules and medications, acid/base balance control, and concentration and dilution of urine. Although well recognized as part of kidney health, these components of tubular function are not systematically captured for overall kidney evaluation in AKI. Recent advances in urinary and serum biomarkers of kidney damage have provided new tools to identify tubular injury that can be mapped to specific sites; however, these injury markers have not been correlated with alterations in tubular function. The combination of tubular function assessment in conjunction with kidney injury, glomerular filtration and permeability markers would provide a more accurate

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK079337-11
Application #
9592095
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2018-08-01
Budget End
2019-07-31
Support Year
11
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
University of Alabama Birmingham
Department
Type
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294

  Publications

Redmann, Matthew; Benavides, Gloria A; Wani, Willayat Yousuf et al. (2018) Methods for assessing mitochondrial quality control mechanisms and cellular consequences in cell culture. Redox Biol 17:59-69
Lever, Jeremie M; Yang, Zhengqin; Boddu, Ravindra et al. (2018) Parabiosis reveals leukocyte dynamics in the kidney. Lab Invest 98:391-402
Pathak, Chetna M; Ix, Joachim H; Anderson, Cheryl A M et al. (2018) Variation in Sodium Intake and Intra-individual Change in Blood Pressure in Chronic Kidney Disease. J Ren Nutr 28:125-128
Thomson, Scott C; Vallon, Volker (2018) Renal Effects of Incretin-Based Diabetes Therapies: Pre-clinical Predictions and Clinical Trial Outcomes. Curr Diab Rep 18:28
Garg, Amit X; Devereaux, P J; Hill, Andrew et al. (2018) Oral curcumin in elective abdominal aortic aneurysm repair: a multicentre randomized controlled trial. CMAJ 190:E1273-E1280
Hepokoski, Mark L; Malhotra, Atul; Singh, Prabhleen et al. (2018) Ventilator-Induced Kidney Injury: Are Novel Biomarkers the Key to Prevention? Nephron 140:90-93
Shin, Boyoung; Kress, Robert L; Kramer, Philip A et al. (2018) Effector CD4 T cells with progenitor potential mediate chronic intestinal inflammation. J Exp Med 215:1803-1812
Alasmari, Fawaz; Crotty Alexander, Laura E; Drummond, Christopher A et al. (2018) A computerized exposure system for animal models to optimize nicotine delivery into the brain through inhalation of electronic cigarette vapors or cigarette smoke. Saudi Pharm J 26:622-628
Layton, Anita T; Vallon, Volker (2018) SGLT2 inhibition in a kidney with reduced nephron number: modeling and analysis of solute transport and metabolism. Am J Physiol Renal Physiol 314:F969-F984
Neyra, Javier A; Leaf, David E (2018) Risk Prediction Models for Acute Kidney Injury in Critically Ill Patients: Opus in Progressu. Nephron 140:99-104

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