Abstract

Pilot Awardee #1: Macedo, Etienne, MD, PhD Title: Tubular Health Characterization in Acute Kidney Injury Despite improvement in AKI classification systems for AKI, timely diagnosis and assessment of AKI severity remains challenging. Renal tubule cells perform many of the essential kidney functions, including reabsorption, electrolyte transport, secretion of endogenous molecules and medications, acid/base balance control, and concentration and dilution of urine. Although well recognized as part of kidney health, these components of tubular function are not systematically captured for overall kidney evaluation in AKI. Recent advances in urinary and serum biomarkers of kidney damage have provided new tools to identify tubular injury that can be mapped to specific sites; however, these injury markers have not been correlated with alterations in tubular function. The combination of tubular function assessment in conjunction with kidney injury, glomerular filtration and permeability markers would provide a more accurate

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK079337-11
Application #
9592095
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2018-08-01
Budget End
2019-07-31
Support Year
11
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
University of Alabama Birmingham
Department
Type
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294

  Publications

Layton, Anita T; Edwards, Aurélie; Vallon, Volker (2018) Renal potassium handling in rats with subtotal nephrectomy: modeling and analysis. Am J Physiol Renal Physiol 314:F643-F657
Li, Mao; Boddeda, Srinivasa Rao; Chen, Bo et al. (2018) NK cell and Th17 responses are differentially induced in murine cytomegalovirus infected renal allografts and vary according to recipient virus dose and strain. Am J Transplant 18:2647-2662
Fu, Yiling; Breljak, Davorka; Onishi, Akira et al. (2018) Organic anion transporter OAT3 enhances the glucosuric effect of the SGLT2 inhibitor empagliflozin. Am J Physiol Renal Physiol 315:F386-F394
Leaf, David E; Siew, Edward D; Eisenga, Michele F et al. (2018) Fibroblast Growth Factor 23 Associates with Death in Critically Ill Patients. Clin J Am Soc Nephrol 13:531-541
Bernard, Karen; Logsdon, Naomi J; Benavides, Gloria A et al. (2018) Glutaminolysis is required for transforming growth factor-?1-induced myofibroblast differentiation and activation. J Biol Chem 293:1218-1228
Singal, Ashwani K; Jackson, Bradford; Pereira, Glauber B et al. (2018) Biomarkers of Renal Injury in Cirrhosis: Association with Acute Kidney Injury and Recovery after Liver Transplantation. Nephron 138:1-12
Crotty Alexander, Laura E; Drummond, Christopher A; Hepokoski, Mark et al. (2018) Chronic inhalation of e-cigarette vapor containing nicotine disrupts airway barrier function and induces systemic inflammation and multiorgan fibrosis in mice. Am J Physiol Regul Integr Comp Physiol 314:R834-R847
Pang, Paul; Abbott, Molly; Abdi, Malyun et al. (2018) Pre-clinical model of severe glutathione peroxidase-3 deficiency and chronic kidney disease results in coronary artery thrombosis and depressed left ventricular function. Nephrol Dial Transplant 33:923-934
Redmann, Matthew; Benavides, Gloria A; Wani, Willayat Yousuf et al. (2018) Methods for assessing mitochondrial quality control mechanisms and cellular consequences in cell culture. Redox Biol 17:59-69
Lever, Jeremie M; Yang, Zhengqin; Boddu, Ravindra et al. (2018) Parabiosis reveals leukocyte dynamics in the kidney. Lab Invest 98:391-402

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