The overall goal of the Interventions and Translation Core (ITC) is to provide expertise and infrastructure to assist investigators with the development, implementation, and evaluation of culturally appropriate interventions. Our objective is to create new knowledge regarding the prevention and management of diabetes and cardiometabolic disease, with an emphasis on reducing health disparities. The ITC?s 3 specific aims are to: 1. Provide expert consultation for intervention development in diabetes prevention and management (e.g., interventions to optimize diet, body weight, exercise/physical activity, medication adherence, and/or glycemic control). This expertise will facilitate translation of basic science findings into efficacy-testing interventions ranging from clinical to community-based trials. 2. Provide expertise on study design and evaluation, including measurement, quality control, quality assurance, and analytic support, for research to prevent and manage diabetes. These studies will include but also go beyond traditional clinical trials. For example, group-randomized trials evaluating weight-loss interventions in community settings require specialized expertise in trial design, data capture and transfer, as well as in interventional and analytic tools. 3. Design and facilitate culturally appropriate strategies to enhance the recruitment and retention of minorities and underserved populations in diabetes-related research studies, with emphasis on African American and rural communities. These core services are based on the expressed needs of funded DRC investigators, and methods will rely on validated, state-of-the-art approaches with a high priority placed on data quality control. The ITC will leverage existing infrastructure for recruitment and community-based research and make cutting edge expertise in intervention development, implementation, and evaluation available to the DRC research base, promoting innovation and advancing the science of diabetes prevention and management.

Public Health Relevance

Research to bridge the gap that separates scientific discovery from clinical practice is sorely needed to counter the diabetes epidemic and improve diabetes related health outcomes.The ITC will provide resources and cutting edge expertise in intervention development, implementation and evaluation for researchers at UAB, to define optimal strategies for diabetes care and prevention in the heart of the Deep South.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
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Special Emphasis Panel (ZDK1)
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University of Alabama Birmingham
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Ovalle, Fernando; Grimes, Tiffany; Xu, Guanlan et al. (2018) Verapamil and beta cell function in adults with recent-onset type 1 diabetes. Nat Med 24:1108-1112
Schneider, C R; Biggio, J R; Chandler-Laney, P C (2018) Association of early pregnancy body mass index with post-partum weight change among African-American women. Clin Obes 8:170-175
Kim, Teayoun; Nason, Shelly; Holleman, Cassie et al. (2018) Glucagon Receptor Signaling Regulates Energy Metabolism via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21. Diabetes 67:1773-1782
Mohler 3rd, Emile R; Ellenberg, Susan S; Lewis, Cora E et al. (2018) The Effect of Testosterone on Cardiovascular Biomarkers in the Testosterone Trials. J Clin Endocrinol Metab 103:681-688
Loomis, Stephanie J; Li, Man; Maruthur, Nisa M et al. (2018) Genome-Wide Association Study of Serum Fructosamine and Glycated Albumin in Adults Without Diagnosed Diabetes: Results From the Atherosclerosis Risk in Communities Study. Diabetes 67:1684-1696
Wingo, Brooks C; Barry, Valene Garr; Ellis, Amy C et al. (2018) Comparison of segmental body composition estimated by bioelectrical impedance analysis and dual-energy X-ray absorptiometry. Clin Nutr ESPEN 28:141-147
Frugé, Andrew D; Cases, Mallory G; Howell, Carrie R et al. (2018) Fingernail and toenail clippings as a non-invasive measure of chronic cortisol levels in adult cancer survivors. Cancer Causes Control 29:185-191
Kim, Teayoun; Holleman, Cassie L; Nason, Shelly et al. (2018) Hepatic Glucagon Receptor Signaling Enhances Insulin-Stimulated Glucose Disposal in Rodents. Diabetes 67:2157-2166
Kreisler, A D; Mattock, M; Zorrilla, E P (2018) The duration of intermittent access to preferred sucrose-rich food affects binge-like intake, fat accumulation, and fasting glucose in male rats. Appetite 130:59-69
Sweatt, S Katherine; Gower, Barbara A; Chieh, Angela Y et al. (2018) Sleep quality is differentially related to adiposity in adults. Psychoneuroendocrinology 98:46-51

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