The Pilot &Feasibility Program has been markedly successful over our first DRC/DRTC cycle. We have impelled career development of junior investigators who received most of these awards (70%), launched innovative projects, and enticed established investigators in other areas to apply their expertise to the study of diabetes. We have had robust responses (average 43/year) to our RFAs every year, and have leveraged institutional support to fund numbers of grants beyond that made possible by NIH support;39 pilots have been awarded to-date, 26 from the NIH DRC allocation, 4 from institutional funds through the Comprehensive Diabetes Center, and 9 through ARRA supplements. All funded applications were judged to be highly meritorious by a rigorous NIH study section-style review process consisting of intramural and extramural experts with an average funding rate of 18%. Recipients have taken advantage of these awards by publishing manuscripts, submitting extramural research applications, and securing larger funding to continue the line of investigation initiated with the pilot award. The pilot program has been a critical tool responsible for the growth in membership numbers and extramural funding of our DRTC/DRC since 2008. Our overall goal for the Pilot &Feasibility Program continues to be to faculitate new research development through pilot projects that synergize with other Cores and Programs in a manner that promotes the overall goals and objectives of the DRC.
The specific aims are: 1.To identify and support new research projects of outstanding quality and innovation for pilot funding, ultimately resulting in larger extramural support for development of the new line of investigation. 2.To support promising junior faculty in career development through funding of outstanding pilot research. 3.To augment the breadth and quality of DRC research by funding innovative projects of established researchers with valuable expertise who are new to diabetes, or of established diabetes investigators who want to test new high-impact hypotheses. 4.To increase the number of independent investigators funded by NIH to conduct diabetes research.

Public Health Relevance

Diabetes is reaching epidemic proportions in the US and the developing world as a whole. The Deep South has suffered a disproportionate increase in the incidence and prevalence of diabetes. In fact, the state of Alabama and surrounding Southeast region served by UAB may be considered the epicenter of the epidemic. Our DRC pilot program will serve as a beacon to address this problem, fostering development of inovative diabetes research and researchers .

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK079626-07
Application #
8640163
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2014-03-01
Budget End
2015-02-28
Support Year
7
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Type
DUNS #
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Gupta, Rajesh; Nguyen, Dan C; Schaid, Michael D et al. (2018) Complement 1q-like-3 protein inhibits insulin secretion from pancreatic ?-cells via the cell adhesion G protein-coupled receptor BAI3. J Biol Chem 293:18086-18098
And, Ay?e; Sylvester, Maria D; Turan, Bulent et al. (2018) The Turkish Palatable Eating Motives Scale (T-PEMS): utility in predicting binge-eating eating and obesity risk in university students. Eat Weight Disord 23:527-531
Ma, Elizabeth; Fu, Yuchang; Garvey, W Timothy (2018) Relationship of Circulating miRNAs with Insulin Sensitivity and Associated Metabolic Risk Factors in Humans. Metab Syndr Relat Disord 16:82-89
Gibbs, Victoria K; Schwartz, Tonia S; Johnson, Maria S et al. (2018) No Significant Effect of Maternal Perception of the Food Environment on Reproductive Success or Pup Outcomes in C57BL/6J Mice. Obesity (Silver Spring) 26:723-729
Demark-Wahnefried, Wendy; Cases, Mallory G; Cantor, Alan B et al. (2018) Pilot Randomized Controlled Trial of a Home Vegetable Gardening Intervention among Older Cancer Survivors Shows Feasibility, Satisfaction, and Promise in Improving Vegetable and Fruit Consumption, Reassurance of Worth, and the Trajectory of Central Adipos J Acad Nutr Diet 118:689-704
Dunham-Snary, Kimberly J; Sandel, Michael W; Sammy, Melissa J et al. (2018) Mitochondrial - nuclear genetic interaction modulates whole body metabolism, adiposity and gene expression in vivo. EBioMedicine 36:316-328
Snyder, Peter J; Bhasin, Shalender; Cunningham, Glenn R et al. (2018) Lessons From the Testosterone Trials. Endocr Rev 39:369-386
Patel, Mikita; Yarlagadda, Vidhush; Adedoyin, Oreoluwa et al. (2018) Oxalate induces mitochondrial dysfunction and disrupts redox homeostasis in a human monocyte derived cell line. Redox Biol 15:207-215
Kang, Minsung; Liu, Xiaobing; Fu, Yuchang et al. (2018) Improved systemic metabolism and adipocyte biology in miR-150 knockout mice. Metabolism 83:139-148
Buford, Thomas W; Carter, Christy S; VanDerPol, William J et al. (2018) Composition and richness of the serum microbiome differ by age and link to systemic inflammation. Geroscience 40:257-268

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