The highly integrated nature ofthe University of Michigan O'Brien Kidney Translational Core Center requires a robust and active Administrative Core, which will coordinate workflow, distribution of resources and operations assessment of the Biomedical Research Cores. In addition the Administrative Core will organize, stimulate and evaluate interactions of the Center with our Institutional and International Research Bases to ensure that the Biomedical Research Cores and educational programs are providing optimal support. The core will also reach out to new faculty and other potential research base members to continue expanding the numbers in both bases. The core will also recruit new investigators to apply to the Pilot and Feasibility Program and will continue to administer this very successful program using expert institutional and external reviewers. The core will modify, update and administer the Center website to ensure that all research base investigators can seamlessly identify and request Center services. Maintaining a vibrant educational environment for kidney research, especially in T1 translational research, continues to be a major goal and the core will modify and implement the effective Educational Enrichment Program. As part of this program, through supplemental NIDDK funding, we have added a Summer Student Research Program for medical students, and support will be sought to maintain this program which will be administered by the core. The Administrative Core also hosted a major symposium on systems biology ofthe kidney in 2012 and the core will continue to promote and support similar ventures. The core will continue to support an Annual Educational Retreat for all research base investigators, including those at our other sites, to highlight translational research approaches, review research progress and obtain feedback on Center services. The core also will continue to help administer the annual C-PROBE retreat for C-PROBE investigators to improve recruitment, retention and management of our growing chronic kidney disease cohort. Throughout all these processes, the core will obtain quality assurance and improvement information from Research Base investigators. The core will host an annual meeting of our Institutional Scientific Advisory Board and our External Advisory Board to obtain advice on progress and new directions. The Administrative Core will also now host the Core Discount Program which largely supports our Institutional Research Base investigators in moving into translational research by providing discounts for using transgenic animal, sequencing and microarray, and histology cores.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK081943-07
Application #
8733669
Study Section
Special Emphasis Panel (ZDK1-GRB-6)
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
7
Fiscal Year
2014
Total Cost
$368,664
Indirect Cost
$131,581
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Mathew, Anna V; Li, Lei; Byun, Jaeman et al. (2018) Therapeutic Lifestyle Changes Improve HDL Function by Inhibiting Myeloperoxidase-Mediated Oxidation in Patients With Metabolic Syndrome. Diabetes Care 41:2431-2437
Skorecki, Karl L; Lee, Jessica H; Langefeld, Carl D et al. (2018) A null variant in the apolipoprotein L3 gene is associated with non-diabetic nephropathy. Nephrol Dial Transplant 33:323-330
Heinzel, Andreas; Kammer, Michael; Mayer, Gert et al. (2018) Validation of Plasma Biomarker Candidates for the Prediction of eGFR Decline in Patients With Type 2 Diabetes. Diabetes Care 41:1947-1954
Wernisch, Stefanie; Afshinnia, Farsad; Rajendiran, Thekkelnaycke et al. (2018) Probing the application range and selectivity of a differential mobility spectrometry-mass spectrometry platform for metabolomics. Anal Bioanal Chem 410:2865-2877
Mariani, Laura H; Martini, Sebastian; Barisoni, Laura et al. (2018) Interstitial fibrosis scored on whole-slide digital imaging of kidney biopsies is a predictor of outcome in proteinuric glomerulopathies. Nephrol Dial Transplant 33:310-318
Verma, Rakesh; Venkatareddy, Madhusudan; Kalinowski, Anne et al. (2018) Nephrin is necessary for podocyte recovery following injury in an adult mature glomerulus. PLoS One 13:e0198013
Troost, Jonathan P; Trachtman, Howard; Nachman, Patrick H et al. (2018) An Outcomes-Based Definition of Proteinuria Remission in Focal Segmental Glomerulosclerosis. Clin J Am Soc Nephrol 13:414-421
Breyer, Matthew D; Kretzler, Matthias (2018) Novel avenues for drug discovery in diabetic kidney disease. Expert Opin Drug Discov 13:65-74
Nair, Viji; Komorowsky, Claudiu V; Weil, E Jennifer et al. (2018) A molecular morphometric approach to diabetic kidney disease can link structure to function and outcome. Kidney Int 93:439-449
Zhong, Fang; Chen, Zhaohong; Zhang, Liwen et al. (2018) Tyro3 is a podocyte protective factor in glomerular disease. JCI Insight 3:

Showing the most recent 10 out of 178 publications