The highly integrated nature ofthe University of Michigan O'Brien Kidney Translational Core Center requires a robust and active Administrative Core, which will coordinate workflow, distribution of resources and operations assessment of the Biomedical Research Cores. In addition the Administrative Core will organize, stimulate and evaluate interactions of the Center with our Institutional and International Research Bases to ensure that the Biomedical Research Cores and educational programs are providing optimal support. The core will also reach out to new faculty and other potential research base members to continue expanding the numbers in both bases. The core will also recruit new investigators to apply to the Pilot and Feasibility Program and will continue to administer this very successful program using expert institutional and external reviewers. The core will modify, update and administer the Center website to ensure that all research base investigators can seamlessly identify and request Center services. Maintaining a vibrant educational environment for kidney research, especially in T1 translational research, continues to be a major goal and the core will modify and implement the effective Educational Enrichment Program. As part of this program, through supplemental NIDDK funding, we have added a Summer Student Research Program for medical students, and support will be sought to maintain this program which will be administered by the core. The Administrative Core also hosted a major symposium on systems biology ofthe kidney in 2012 and the core will continue to promote and support similar ventures. The core will continue to support an Annual Educational Retreat for all research base investigators, including those at our other sites, to highlight translational research approaches, review research progress and obtain feedback on Center services. The core also will continue to help administer the annual C-PROBE retreat for C-PROBE investigators to improve recruitment, retention and management of our growing chronic kidney disease cohort. Throughout all these processes, the core will obtain quality assurance and improvement information from Research Base investigators. The core will host an annual meeting of our Institutional Scientific Advisory Board and our External Advisory Board to obtain advice on progress and new directions. The Administrative Core will also now host the Core Discount Program which largely supports our Institutional Research Base investigators in moving into translational research by providing discounts for using transgenic animal, sequencing and microarray, and histology cores.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1-GRB-6)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Michigan Ann Arbor
Ann Arbor
United States
Zip Code
Galla, S; Chakraborty, S; Cheng, X et al. (2018) Disparate effects of antibiotics on hypertension. Physiol Genomics 50:837-845
Brosius, Frank C; Ju, Wenjun (2018) The Promise of Systems Biology for Diabetic Kidney Disease. Adv Chronic Kidney Dis 25:202-213
Bria, Carmen R M; Afshinnia, Farsad; Skelly, Patrick W et al. (2018) Asymmetrical flow field-flow fractionation for improved characterization of human plasma lipoproteins. Anal Bioanal Chem :
Troost, Jonathan P; Hawkins, Jennifer; Jenkins, Daniel R et al. (2018) Consent for Genetic Biobanking in a Diverse Multisite CKD Cohort. Kidney Int Rep 3:1267-1275
Zeng, Lixia; Mathew, Anna V; Byun, Jaeman et al. (2018) Myeloperoxidase-derived oxidants damage artery wall proteins in an animal model of chronic kidney disease-accelerated atherosclerosis. J Biol Chem 293:7238-7249
Mulder, Skander; Hamidi, Habib; Kretzler, Matthias et al. (2018) An integrative systems biology approach for precision medicine in diabetic kidney disease. Diabetes Obes Metab 20 Suppl 3:6-13
Duda, Marlena; Zhang, Hongjiu; Li, Hong-Dong et al. (2018) Brain-specific functional relationship networks inform autism spectrum disorder gene prediction. Transl Psychiatry 8:56
Afshinnia, Farsad; Rajendiran, Thekkelnaycke M; Wernisch, Stefanie et al. (2018) Lipidomics and Biomarker Discovery in Kidney Disease. Semin Nephrol 38:127-141
Jadoon, Adil; Mathew, Anna V; Byun, Jaeman et al. (2018) Gut Microbial Product Predicts Cardiovascular Risk in Chronic Kidney Disease Patients. Am J Nephrol 48:269-277
Mathew, Anna V; Li, Lei; Byun, Jaeman et al. (2018) Therapeutic Lifestyle Changes Improve HDL Function by Inhibiting Myeloperoxidase-Mediated Oxidation in Patients With Metabolic Syndrome. Diabetes Care 41:2431-2437

Showing the most recent 10 out of 178 publications