The Bioinformatics Core is an important component ofthe Michigan O'Brien Kidney Translational Core Center. This core will provide access to computational applications and skilled professional support in bioinformatics and biostatistics Increasingly large and complex data sets require computational support for analyses, and the presence of this core will enhance the research. The Bioinformatics Core will provide analytical support for large datasets including microarray, and next generations sequencing applications for genomics, transcriptomics, proteomics and epigenetics. The Bioinformatics Core is aligned to the overall goals ofthe Center and will provide focused, specific support for researchers studying chronic kidney disease. To be successful, this core will provide guidance and assistance to Center researchers at all stages of research from experimental design to data generation and analysis of molecular profiling data. The Bioinformatics Core will be fully integrated with the DNA sequencing core for smooth coordination of data transfer and analysis. The system's biology core will also be integrated with the Bioinformatics Core to provide deeper analysis ofthe project data and combine the different molecular profiling analyses.
Bioinformatics and biostatistics are essential for the analysis and interpretation of large data sets. The inclusion of this core to the Michigan O'Brien center is crucial to providing complete support for chronic kidney disease researchers.
| Mariani, Laura H; Martini, Sebastian; Barisoni, Laura et al. (2018) Interstitial fibrosis scored on whole-slide digital imaging of kidney biopsies is a predictor of outcome in proteinuric glomerulopathies. Nephrol Dial Transplant 33:310-318 |
| Verma, Rakesh; Venkatareddy, Madhusudan; Kalinowski, Anne et al. (2018) Nephrin is necessary for podocyte recovery following injury in an adult mature glomerulus. PLoS One 13:e0198013 |
| Troost, Jonathan P; Trachtman, Howard; Nachman, Patrick H et al. (2018) An Outcomes-Based Definition of Proteinuria Remission in Focal Segmental Glomerulosclerosis. Clin J Am Soc Nephrol 13:414-421 |
| Breyer, Matthew D; Kretzler, Matthias (2018) Novel avenues for drug discovery in diabetic kidney disease. Expert Opin Drug Discov 13:65-74 |
| Nair, Viji; Komorowsky, Claudiu V; Weil, E Jennifer et al. (2018) A molecular morphometric approach to diabetic kidney disease can link structure to function and outcome. Kidney Int 93:439-449 |
| Zhong, Fang; Chen, Zhaohong; Zhang, Liwen et al. (2018) Tyro3 is a podocyte protective factor in glomerular disease. JCI Insight 3: |
| Galla, S; Chakraborty, S; Cheng, X et al. (2018) Disparate effects of antibiotics on hypertension. Physiol Genomics 50:837-845 |
| Brosius, Frank C; Ju, Wenjun (2018) The Promise of Systems Biology for Diabetic Kidney Disease. Adv Chronic Kidney Dis 25:202-213 |
| Bria, Carmen R M; Afshinnia, Farsad; Skelly, Patrick W et al. (2018) Asymmetrical flow field-flow fractionation for improved characterization of human plasma lipoproteins. Anal Bioanal Chem : |
| Troost, Jonathan P; Hawkins, Jennifer; Jenkins, Daniel R et al. (2018) Consent for Genetic Biobanking in a Diverse Multisite CKD Cohort. Kidney Int Rep 3:1267-1275 |
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