A requisite step for translating laboratory-based discoveries into human treatments is the process of demonstrating proof-in-concept of in vitro signaling paradigms within human tissues. Despite the numerous signaling strengths of the Research Base that comprises this Center Grant proposal, surveys of this base revealed an unmet need to enhance the availability of human biological samples and downstream state-ofart technologies that can be carried out with these samples by the Research Base. In order to meet this need, we propose a Clinical Core, which will maintain two linked Objectives: first;to facilitate the collection and annotation of Gl biospecimens that can enhance the translational research of each of the 3 Disease Focus Areas contained within this grant (enteric neurosciences, liver pathobiology, and carcinogenesis), and second;to provide subsidized, yet state-of-the-art technologies with which the Research Base can use these biospecimens to translate signaling research within the paradigm of human specimens. These Objectives will be achieved by: i.) integration of existing tissue collections and annotated data into a collaborative webbased organizational structure that will be easily accessible by the Research Base;ii.) providing support to expand current tissue collections and initiate collection of biospecimens representing additional digestive disease states;iii.) linking the Research Base with expert intramural facilities that can provide essential technologies using human specimens including, but not limited to, tissue microarray, laser capture microdissection linked with PCR, and others, through a subsidized mechanism;and, v.) providing skilled technologist support to perform biospecimen processing tasks either not supported by intramural facilities or that require Gl specific-expertise. Thus, this Clinical Core will provide its Research Base with a cost effective approach by which to collaboratively translate Gl signaling paradigms into human tissues using state-of-art technologies.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1-GRB-8)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Mayo Clinic, Rochester
United States
Zip Code
Mouchli, Mohamad A; Singh, Siddharth; Boardman, Lisa et al. (2018) Natural History of Established and De Novo Inflammatory Bowel Disease After Liver Transplantation for Primary Sclerosing Cholangitis. Inflamm Bowel Dis 24:1074-1081
Paradise, Brooke D; Barham, Whitney; Fernandez-Zapico, Martín E (2018) Targeting Epigenetic Aberrations in Pancreatic Cancer, a New Path to Improve Patient Outcomes? Cancers (Basel) 10:
Banales, Jesus M; Marzioni, Marco; LaRusso, Nicholas F et al. (2018) Cholangiocytes in health and disease: From basic science to novel treatments. Biochim Biophys Acta Mol Basis Dis 1864:1217-1219
Tarragó, Mariana G; Chini, Claudia C S; Kanamori, Karina S et al. (2018) A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline. Cell Metab 27:1081-1095.e10
Kim, Minsoo; Druliner, Brooke R; Vasmatzis, Nikolaos et al. (2018) Inferring modes of evolution from colorectal cancer with residual polyp of origin. Oncotarget 9:6780-6792
Druliner, Brooke R; Wang, Panwen; Bae, Taejeong et al. (2018) Molecular characterization of colorectal adenomas with and without malignancy reveals distinguishing genome, transcriptome and methylome alterations. Sci Rep 8:3161
Mansini, Adrian P; Lorenzo Pisarello, Maria J; Thelen, Kristen M et al. (2018) MicroRNA (miR)-433 and miR-22 dysregulations induce histone-deacetylase-6 overexpression and ciliary loss in cholangiocarcinoma. Hepatology 68:561-573
Moncsek, Anja; Al-Suraih, Mohammed S; Trussoni, Christy E et al. (2018) Targeting senescent cholangiocytes and activated fibroblasts with B-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2-/- ) mice. Hepatology 67:247-259
Allen, Alina M; Shah, Vijay H; Therneau, Terry M et al. (2018) The role of 3D-MRE in the diagnosis of NASH in obese patients undergoing bariatric surgery. Hepatology :
Dhanasekaran, Renumathy; Nault, Jean-Charles; Roberts, Lewis R et al. (2018) Genomic Medicine and Implications for Hepatocellular Carcinoma Prevention and Therapy. Gastroenterology :

Showing the most recent 10 out of 537 publications