Overview In line with grant requirements, the C-SiG Pilot and Feasibility (P/F) Program: 1) Supports both new investigators just beginning their careers in digestive diseases research or innovative research proposals from experienced investigators who plan to change their area of research;ii) Provides investigators with vital funds to obtain preliminary data that support research grant applications from external agencies, especially NIH ROl grant submissions;and, iii) Provides mentorship, critical review of proposals, and coaching to improve the competitiveness of grant applications. We are strongly focused on junior investigators and Mayo Clinic has a sustained and rich tradition of facilitating the transition of junior investigators to independent scientists. As of February 2013, there were 1932 fellows (1311 MD (or equivalent), 130 MD/PhD, and 491 PhD) and 113 research trainees at Mayo Clinic Rochester. The Division of Gastroenterology and Hepatology (GIH) had a total of 82 fellows (36 fellows in the clinical training program, 5 fellows on our longstanding NIH Gl training grant, 41 postdoctoral research fellows) and 15 research trainees. GIH junior investigators comprise 26% of P/F applicants and 46% of the awardees. The C-SiG P/F Program works closely with the GIH Division and other Departments and Centers to help junior investigators achieve independent funding and to bring experienced investigators with C-SiG-relevant expertise into digestive disease research.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Mayo Clinic, Rochester
United States
Zip Code
Smoot, Rory L; Werneburg, Nathan W; Sugihara, Takaaki et al. (2018) Platelet-derived growth factor regulates YAP transcriptional activity via Src family kinase dependent tyrosine phosphorylation. J Cell Biochem 119:824-836
Masyuk, Tatyana V; Masyuk, Anatoliy I; LaRusso, Nicholas F (2018) Polycystic liver disease: The interplay of genes causative for hepatic and renal cystogenesis. Hepatology 67:2462-2464
Alcaino, Constanza; Knutson, Kaitlyn R; Treichel, Anthony J et al. (2018) A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release. Proc Natl Acad Sci U S A 115:E7632-E7641
Hale, Vanessa L; Jeraldo, Patricio; Mundy, Michael et al. (2018) Synthesis of multi-omic data and community metabolic models reveals insights into the role of hydrogen sulfide in colon cancer. Methods 149:59-68
Lorenzo Pisarello, Maria; Masyuk, Tatyana V; Gradilone, Sergio A et al. (2018) Combination of a Histone Deacetylase 6 Inhibitor and a Somatostatin Receptor Agonist Synergistically Reduces Hepatorenal Cystogenesis in an Animal Model of Polycystic Liver Disease. Am J Pathol 188:981-994
Rizvi, Sumera; Gores, Gregory J (2018) Fibroblast Growth Factor Receptor Inhibition for Cholangiocarcinoma: Looking Through a Door Half-Opened. Hepatology 68:2428-2430
Cheung, Angela C; Lorenzo Pisarello, Maria J; LaRusso, Nicholas F (2018) Pathobiology of biliary epithelia. Biochim Biophys Acta Mol Basis Dis 1864:1220-1231
Yang, Ju Dong; Addissie, Benyam D; Mara, Kristin C et al. (2018) GALAD Score for Hepatocellular Carcinoma Detection in Comparison to Liver Ultrasound and Proposal of GALADUS Score. Cancer Epidemiol Biomarkers Prev :
Fukushima, Masanori; Dasgupta, Debanjali; Mauer, Amy S et al. (2018) StAR-related lipid transfer domain 11 (STARD11)-mediated ceramide transport mediates extracellular vesicle biogenesis. J Biol Chem 293:15277-15289
Dou, Changwei; Liu, Zhikui; Tu, Kangsheng et al. (2018) P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-Promoting Myofibroblasts. Gastroenterology 154:2209-2221.e14

Showing the most recent 10 out of 537 publications