Abstract

Two pre-existing functional Core Facilities will be merged under this proposal and focused on supporting the UPENN/CHOP program in benign hematopoiesis. This combined service will be entitled the Human Stem Cell Core B and will be directed by Dr. Mitchell Weiss. The two SubCores are 1) SubCore B-1, the Hematopoietic Stem Cell (HSC) Facility at UPENN, directed by Martin Carroll, and 2) SubCore B-2, the Human Embryonic Stem (ES) and Induced Pluripotent Stem (iPS) Cell Facility, which is physically present at CHOP, and will be directed by Dr. Deborah French.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK090969-04
Application #
8507221
Study Section
Special Emphasis Panel (ZDK1-GRB-G)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
4
Fiscal Year
2013
Total Cost
$312,556
Indirect Cost
$49,257

  Institution

Name
Children's Hospital of Philadelphia
Department
Type
DUNS #
073757627
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Cheng, Ying; Chikwava, Kudakwashe; Wu, Chao et al. (2016) LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors. J Clin Invest 126:1267-81
Wang, Yuhuan; Hayes, Vincent; Jarocha, Danuta et al. (2015) Comparative analysis of human ex vivo-generated platelets vs megakaryocyte-generated platelets in mice: a cautionary tale. Blood 125:3627-36
Gu, Bai-Wei; Apicella, Marisa; Mills, Jason et al. (2015) Impaired Telomere Maintenance and Decreased Canonical WNT Signaling but Normal Ribosome Biogenesis in Induced Pluripotent Stem Cells from X-Linked Dyskeratosis Congenita Patients. PLoS One 10:e0127414
Byrska-Bishop, Marta; VanDorn, Daniel; Campbell, Amy E et al. (2015) Pluripotent stem cells reveal erythroid-specific activities of the GATA1 N-terminus. J Clin Invest 125:993-1005
Ivanovska, Irena L; Shin, Jae-Won; Swift, Joe et al. (2015) Stem cell mechanobiology: diverse lessons from bone marrow. Trends Cell Biol 25:523-32
Rozenova, Krasimira; Jiang, Jing; Donaghy, Ryan et al. (2015) MERIT40 deficiency expands hematopoietic stem cell pools by regulating thrombopoietin receptor signaling. Blood 125:1730-8
Noh, Ji-Yoon; Gandre-Babbe, Shilpa; Wang, Yuhuan et al. (2015) Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells. J Clin Invest 125:2369-74
Dingal, P C Dave P; Bradshaw, Andrew M; Cho, Sangkyun et al. (2015) Fractal heterogeneity in minimal matrix models of scars modulates stiff-niche stem-cell responses via nuclear exit of a mechanorepressor. Nat Mater 14:951-60
Dogan, Nergiz; Wu, Weisheng; Morrissey, Christapher S et al. (2015) Occupancy by key transcription factors is a more accurate predictor of enhancer activity than histone modifications or chromatin accessibility. Epigenetics Chromatin 8:16
Jain, Deepti; Mishra, Tejaswini; Giardine, Belinda M et al. (2015) Dynamics of GATA1 binding and expression response in a GATA1-induced erythroid differentiation system. Genom Data 4:1-7

Showing the most recent 10 out of 46 publications