Abstract

The Administrative Core (Director: James Calvet; Associate Director: Darren Wallace) will be responsible for overseeing all Center activities. It will set the overall direction of these activities by prioritizing the scientific direction, coordinating and integrating all of the Center's functions, managing the overall budget, establishing and delineating areas of research emphasis, and promoting internal and external collaborative interactions. The Administrative Core will also be responsible for regular external review of core services and the P&F program, and will work to strengthen interactions between the Center and KUMC administration by interfacing its activities with other programs, centers, institutes, and existing institutional shared resources. The Administrative Core will also interface with national PKD Centers of Excellence and PKD research groups nationally through its educational outreach programs to ensure the effectiveness and overall visibility and impact of the Kansas PKD Center and its research scientists and clinical investigators.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
1P30DK106912-01
Application #
8973945
Study Section
Special Emphasis Panel (ZDK1-GRB-G (M5))
Project Start
Project End
Budget Start
2015-09-15
Budget End
2016-06-30
Support Year
1
Fiscal Year
2015
Total Cost
$110,464
Indirect Cost
$37,309

  Institution

Name
University of Kansas
Department
Type
DUNS #
016060860
City
Fairway
State
KS
Country
United States
Zip Code
66025

  Publications

Yu, Alan S L; Shen, Chengli; Landsittel, Douglas P et al. (2018) Baseline total kidney volume and the rate of kidney growth are associated with chronic kidney disease progression in Autosomal Dominant Polycystic Kidney Disease. Kidney Int 93:691-699
Billot, Katy; Coquil, Charlène; Villiers, Benoit et al. (2018) Casein kinase 1? and 1? as novel players in polycystic kidney disease and mechanistic targets for (R)-roscovitine and (S)-CR8. Am J Physiol Renal Physiol 315:F57-F73
Idowu, Jessica; Home, Trisha; Patel, Nisha et al. (2018) Aberrant Regulation of Notch3 Signaling Pathway in Polycystic Kidney Disease. Sci Rep 8:3340
Nowak, Kristen L; You, Zhiying; Gitomer, Berenice et al. (2018) Overweight and Obesity Are Predictors of Progression in Early Autosomal Dominant Polycystic Kidney Disease. J Am Soc Nephrol 29:571-578
Lea, Wendy A; Parnell, Stephen C; Wallace, Darren P et al. (2018) Human-Specific Abnormal Alternative Splicing of Wild-Type PKD1 Induces Premature Termination of Polycystin-1. J Am Soc Nephrol 29:2482-2492
Li, Linda Xiaoyan; Zhou, Julie Xia; Calvet, James P et al. (2018) Lysine methyltransferase SMYD2 promotes triple negative breast cancer progression. Cell Death Dis 9:326
Silva, Luciane M; Jacobs, Damon T; Allard, Bailey A et al. (2018) Inhibition of Hedgehog signaling suppresses proliferation and microcyst formation of human Autosomal Dominant Polycystic Kidney Disease cells. Sci Rep 8:4985
Parnell, Stephen C; Magenheimer, Brenda S; Maser, Robin L et al. (2018) A mutation affecting polycystin-1 mediated heterotrimeric G-protein signaling causes PKD. Hum Mol Genet 27:3313-3324
Tomilin, Viktor; Reif, Gail A; Zaika, Oleg et al. (2018) Deficient transient receptor potential vanilloid type 4 function contributes to compromised [Ca2+]i homeostasis in human autosomal-dominant polycystic kidney disease cells. FASEB J 32:4612-4623
Raman, Archana; Parnell, Stephen C; Zhang, Yan et al. (2018) Periostin overexpression in collecting ducts accelerates renal cyst growth and fibrosis in polycystic kidney disease. Am J Physiol Renal Physiol :

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