Center overview abstract The Stanford Diabetes Research Center (SDRC) embodies the culmination of a long-term strategic plan by the Stanford University School of Medicine to create a premier program founded on a base of superb, collaborative investigators studying basic, clinical and translational problems focused on improving diabetes care. Support of this P30 application will leverage diabetes research at Stanford University by providing key resources dedicated to supporting research, training and clinical activities focused on diabetes. Stanford has a well- known tradition and reputation for academic excellence, scientific innovation, and clinical care, united in a true University located on a single campus that facilitates and encourages interaction between scientists and clinicians from different disciplines. Stanford is the heart of Silicon Valley, an epicenter of innovation and calculated risk-taking, whose technology companies, start-ups, and mobile health companies partner with SDRC faculty in unique and growing collaborations to advance diabetes research and care. The SDRC is comprised of 94 investigators in 23 departments from the Schools of Medicine, Engineering, and Humanities & Sciences. The SDRC mission is to foster innovation, new knowledge, and training in basic and translational diabetes-related research, leading to improved diagnosis, treatment and prevention of diabetes and its complications. The SDRC consists of: 1) Administrative Component that coordinates the scientific, organizational, and outreach activities; 2) Biomedical Research Component that recruits and selects SDRC- affiliated investigators and supervises the research cores that facilitate and enhance their research; 3) Pilot and Feasibility Program that facilitates the development of new investigators into independent scientists and encourages scientists in other fields to enter the field of diabetes research; and 4) Enrichment, Training, and Outreach Program that fosters an environment conducive to collaborative, interdisciplinary research on diabetes. NIH support for the SDRC is greatly amplified by: 1) Stanford's sustained commitment to provide research space and additional financial resources; 2) a diverse, comprehensive array of research core services at Stanford, which allows NIH funds to support unique, diabetes-related research cores; and 3) collaborative efforts with other NIH-funded research centers at Stanford. The SDRC is evolving and dynamic, including additions to its investigator base and research areas, expanded focus on clinical and translational research, and evolution of core support to provide unique, indispensable core services devoted to diabetes research. Because of the strategic plan to create a strong Stanford Diabetes Research Center, and the culture of innovation this Center at Stanford creates, SCRC-affiliated investigators have made and are poised to continue making important scientific contributions related to diabetes, obesity, and metabolism.

Public Health Relevance

Project_Narrative: Overall This P30 application from the Stanford Diabetes Research Center (SDRC) seeks support for its efforts to discover, apply and translate science about diabetes and it complications, with the goal of improving health by reducing the burden of diabetes. The SDRC is founded on a base of superb, collaborative investigators studying basic, clinical and translational problems in diabetes at Stanford University, which has a tradition and reputation for scientific innovation and clinical care, located in the heart of Silicon Valley, an epicenter of transformative discovery and calculated risk-taking. Support of this P30 application will leverage diabetes research at Stanford University by providing key resources to support Research Cores, and a Pilot and Feasibility Award Program to foster innovative diabetes research, and Enrichment Programs focused on diabetes research, education and care.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Center Core Grants (P30)
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Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Hyde, James F
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Stanford University
Anatomy/Cell Biology
Schools of Medicine
United States
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Arda, H Efsun; Tsai, Jennifer; Rosli, Yenny R et al. (2018) A Chromatin Basis for Cell Lineage and Disease Risk in the Human Pancreas. Cell Syst 7:310-322.e4
Deng, Bing; Shen, Wen-Jun; Dong, Dachuan et al. (2018) Plasma membrane cholesterol trafficking in steroidogenesis. FASEB J :fj201800697RRR
Singh, Madhurima; Bittner, Stefanie; Li, Yihang et al. (2018) Anti-hyperlipidaemic effects of synthetic analogues of nordihydroguaiaretic acid in dyslipidaemic rats. Br J Pharmacol :
DeSalvo, Daniel J; Miller, Kellee M; Hermann, Julia M et al. (2018) Continuous glucose monitoring and glycemic control among youth with type 1 diabetes: International comparison from the T1D Exchange and DPV Initiative. Pediatr Diabetes 19:1271-1275
Poon, Anna K; Meyer, Michelle L; Reaven, Gerald et al. (2018) Short-Term Repeatability of Insulin Resistance Indexes in Older Adults: The Atherosclerosis Risk in Communities Study. J Clin Endocrinol Metab 103:2175-2181
Ingelsson, Erik; McCarthy, Mark I (2018) Human Genetics of Obesity and Type 2 Diabetes Mellitus: Past, Present, and Future. Circ Genom Precis Med 11:e002090
Peiris, Heshan; Park, Sangbin; Louis, Shreya et al. (2018) Discovering human diabetes-risk gene function with genetics and physiological assays. Nat Commun 9:3855
Singh, Amar Bahadur; Dong, Bin; Kraemer, Fredric B et al. (2018) Farnesoid X Receptor Activation by Obeticholic Acid Elevates Liver Low-Density Lipoprotein Receptor Expression by mRNA Stabilization and Reduces Plasma Low-Density Lipoprotein Cholesterol in Mice. Arterioscler Thromb Vasc Biol 38:2448-2459
Chan, Jackie K W; Bittner, Stefanie; Bittner, Alex et al. (2018) Nordihydroguaiaretic Acid, a Lignan from Larrea tridentata (Creosote Bush), Protects Against American Lifestyle-Induced Obesity Syndrome Diet-Induced Metabolic Dysfunction in Mice. J Pharmacol Exp Ther 365:281-290
Zanetti, Daniela; Tikkanen, Emmi; Gustafsson, Stefan et al. (2018) Birthweight, Type 2 Diabetes Mellitus, and Cardiovascular Disease: Addressing the Barker Hypothesis With Mendelian Randomization. Circ Genom Precis Med 11:e002054

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