Abstract

This research and research training program emphasizes a variety of laboratory studies and epidemiologic approaches to the study of the effects of environmental and occupational factors on the health of man. Specific examples include the following: biology of alveolar macrophages as a pulmonary defense mechanism; effects of breathing pattern and lung volume on the distribution of inhaled particles; development and exploitation of differentiated mammalian cell culture systems to detect, examine the mechanisms of action, and develop means for prevention or reversal of certain environmental chemical toxic agents; development of new chemical and immunologic assay methods for certain classes of environmental chemicals; development and use of affinity probes to identify the sites and molecular mechanisms of action of specific toxic agents; malignant transformation in vitro; cancer morbidity and mortality among rubber workers; pulmonary function changes in granite dust exposures, toluene di-isocyanate exposures, and other occupational exposures; the uses of proportional mortality analysis in identifying suspected occupational exposures; a prospective study of children and adults exposed to specific indoor and outdoor air pollutants.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES000002-23
Application #
3102210
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
1977-12-01
Project End
1987-11-30
Budget Start
1984-12-01
Budget End
1985-11-30
Support Year
23
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Harvard University
Department
Type
Schools of Public Health
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code

  Publications

Orta, Olivia R; Tworoger, Shelley S; Terry, Kathryn L et al. (2018) An evaluation of distal hair cortisol concentrations collected at delivery. Stress 21:355-365
Carignan, Courtney C; Mínguez-Alarcón, Lidia; Williams, Paige L et al. (2018) Paternal urinary concentrations of organophosphate flame retardant metabolites, fertility measures, and pregnancy outcomes among couples undergoing in vitro fertilization. Environ Int 111:232-238
Yitshak-Sade, Maayan; Bobb, Jennifer F; Schwartz, Joel D et al. (2018) The association between short and long-term exposure to PM2.5 and temperature and hospital admissions in New England and the synergistic effect of the short-term exposures. Sci Total Environ 639:868-875
North, Crystal M; Allen, Joseph G; Okello, Samson et al. (2018) HIV Infection, Pulmonary Tuberculosis, and COPD in Rural Uganda: A Cross-Sectional Study. Lung 196:49-57
Greenspan, Louise C; Lee, Mary M (2018) Endocrine disrupters and pubertal timing. Curr Opin Endocrinol Diabetes Obes 25:49-54
Li, Wenyuan; Dorans, Kirsten S; Wilker, Elissa H et al. (2018) Ambient air pollution, adipokines, and glucose homeostasis: The Framingham Heart Study. Environ Int 111:14-22
Draz, Mohamed Shehata; Venkataramani, Manasa; Lakshminarayanan, Harini et al. (2018) Nanoparticle-enhanced electrical detection of Zika virus on paper microchips. Nanoscale 10:11841-11849
Mínguez-Alarcón, Lidia; Afeiche, Myriam C; Williams, Paige L et al. (2018) Hair mercury (Hg) levels, fish consumption and semen parameters among men attending a fertility center. Int J Hyg Environ Health 221:174-182
Messerlian, Carmen; Williams, Paige L; Ford, Jennifer B et al. (2018) The Environment and Reproductive Health (EARTH) Study: A Prospective Preconception Cohort. Hum Reprod Open 2018:
Li, Wenyuan; Nyhan, Marguerite M; Wilker, Elissa H et al. (2018) Recent exposure to particle radioactivity and biomarkers of oxidative stress and inflammation: The Framingham Heart Study. Environ Int 121:1210-1216

Showing the most recent 10 out of 1142 publications