Abstract

This research and research training program emphasizes a variety of laboratory studies and epidemiologic approaches to the study of the effects of environmental and occupational factors on the health of man. Specific examples include the following: biology of alveolar macrophages as a pulmonary defense mechanism; effects of breathing pattern and lung volume on the distribution of inhaled particles; development and exploitation of differentiated mammalian cell culture systems to detect, examine the mechanisms of action, and develop means for prevention or reversal of certain environmental chemical toxic agents; development of new chemical and immunologic assay methods for certain classes of environmental chemicals; development and use of affinity probes to identify the sites and molecular mechanisms of action of specific toxic agents; malignant transformation in vitro; cancer morbidity and mortality among rubber workers; pulmonary function changes in granite dust exposures, toluene di-isocyanate exposures, and other occupational exposures; the uses of proportional mortality analysis in identifying suspected occupational exposures; a prospective study of children and adults exposed to specific indoor and outdoor air pollutants.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES000002-25
Application #
3102212
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
1977-12-01
Project End
1987-11-30
Budget Start
1986-12-01
Budget End
1987-11-30
Support Year
25
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Harvard University
Department
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Lai, Peggy S; Kolde, Raivo; Franzosa, Eric A et al. (2018) The classroom microbiome and asthma morbidity in children attending 3 inner-city schools. J Allergy Clin Immunol 141:2311-2313
Flom, Julie D; Chiu, Yueh-Hsiu Mathilda; Hsu, Hsiao-Hsien Leon et al. (2018) Maternal Lifetime Trauma and Birthweight: Effect Modification by In Utero Cortisol and Child Sex. J Pediatr 203:301-308
Zhao, Jiayuan; Zhang, Yipei; Sisler, Jennifer D et al. (2018) Assessment of reactive oxygen species generated by electronic cigarettes using acellular and cellular approaches. J Hazard Mater 344:549-557
Zhao, Jiayuan; Nelson, Jordan; Dada, Oluwabunmi et al. (2018) Assessing electronic cigarette emissions: linking physico-chemical properties to product brand, e-liquid flavoring additives, operational voltage and user puffing patterns. Inhal Toxicol 30:78-88
Gregory, David J; Kramnik, Igor; Kobzik, Lester (2018) Protection of macrophages from intracellular pathogens by miR-182-5p mimic-a gene expression meta-analysis approach. FEBS J 285:244-260
Shen, Sipeng; Zhang, Ruyang; Zhang, Jinming et al. (2018) Welding fume exposure is associated with inflammation: a global metabolomics profiling study. Environ Health 17:68
Thomas, Dennis G; Smith, Jordan N; Thrall, Brian D et al. (2018) ISD3: a particokinetic model for predicting the combined effects of particle sedimentation, diffusion and dissolution on cellular dosimetry for in vitro systems. Part Fibre Toxicol 15:6
Dickerson, Aisha S; Hansen, Johnni; Gredal, Ole et al. (2018) Amyotrophic lateral sclerosis and exposure to diesel exhaust in a Danish cohort. Am J Epidemiol :
Machtinger, Ronit; Gaskins, Audrey J; Racowsky, Catherine et al. (2018) Urinary concentrations of biomarkers of phthalates and phthalate alternatives and IVF outcomes. Environ Int 111:23-31
Aris, Izzuddin M; Rifas-Shiman, Sheryl L; Li, Ling-Jun et al. (2018) Pre-, Perinatal, and Parental Predictors of Body Mass Index Trajectory Milestones. J Pediatr 201:69-77.e8

Showing the most recent 10 out of 1142 publications