Abstract

This research and research training program emphasizes a variety of laboratory studies and epidemiologic approaches to the study of the effects of environmental and occupational factors on the health of man. Specific examples include the following: biology of alveolar macrophages as a pulmonary defense mechanism; effects of breathing pattern and lung volume on the distribution of inhaled particles; development and exploitation of differentiated mammalian cell culture systems to detect, examine the mechanisms of action, and develop means for prevention or reversal of certain environmental chemical toxic agents; development of new chemical and immunologic assay methods for certain classes of environmental chemicals; development and use of affinity probes to identify the sites and molecular mechanisms of action of specific toxic agents; malignant transformation in vitro; cancer morbidity and mortality among rubber workers; pulmonary function changes in granite dust exposures, toluene di-isocyanate exposures, and other occupational exposures; the uses of proportional mortality analysis in identifying suspected occupational exposures; a prospective study of children and adults exposed to specific indoor and outdoor air pollutants.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES000002-25
Application #
3102212
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
1977-12-01
Project End
1987-11-30
Budget Start
1986-12-01
Budget End
1987-11-30
Support Year
25
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Harvard University
Department
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Blomberg, Annelise J; Coull, Brent A; Jhun, Iny et al. (2018) Effect modification of ambient particle mortality by radon: a time series analysis in 108 U.S. cities. J Air Waste Manag Assoc :
Hopp, Stephanie; Dominici, Francesca; Bobb, Jennifer F (2018) Medical diagnoses of heat wave-related hospital admissions in older adults. Prev Med 110:81-85
Konduru, Nagarjun V; Damiani, Flavia; Stoilova-McPhie, Svetla et al. (2018) Nanoparticle Wettability Influences Nanoparticle-Phospholipid Interactions. Langmuir 34:6454-6461
Rodosthenous, Rodosthenis S; Kloog, Itai; Colicino, Elena et al. (2018) Extracellular vesicle-enriched microRNAs interact in the association between long-term particulate matter and blood pressure in elderly men. Environ Res 167:640-649
Rodan, Lance H; Hauptman, Marissa; D'Gama, Alissa M et al. (2018) Novel founder intronic variant in SLC39A14 in two families causing Manganism and potential treatment strategies. Mol Genet Metab 124:161-167
Woo, May K; Young, Elisabeth S; Mostofa, Md Golam et al. (2018) Lead in Air in Bangladesh: Exposure in a Rural Community with Elevated Blood Lead Concentrations among Young Children. Int J Environ Res Public Health 15:
Bose, Sonali; Rosa, Maria José; Mathilda Chiu, Yueh-Hsiu et al. (2018) Prenatal nitrate air pollution exposure and reduced child lung function: Timing and fetal sex effects. Environ Res 167:591-597
Wang, Qiyu; Yu, Jiujiu; Kadungure, Tatenda et al. (2018) ARMMs as a versatile platform for intracellular delivery of macromolecules. Nat Commun 9:960
Mostofsky, Elizabeth; Coull, Brent A; Mittleman, Murray A (2018) Analysis of Observational Self-matched Data to Examine Acute Triggers of Outcome Events with Abrupt Onset. Epidemiology 29:804-816
Bobb, Jennifer F; Claus Henn, Birgit; Valeri, Linda et al. (2018) Statistical software for analyzing the health effects of multiple concurrent exposures via Bayesian kernel machine regression. Environ Health 17:67

Showing the most recent 10 out of 1142 publications