The objectives of our Harvard Kresge Center for Environmental Health are to generate new knowledge relating to the physiology, pharmacology, pathology, cell biology, and epidemiology of environmental disease, and to apply this knowledge to new modalities of therapy and prevention. We intend to realize these objective through a variety of approaches which range from studies of molecules and cells to those of whole animals and human populations. Through the organizational structure and financial support provided by the NIEHS Center Grant, we hope to increase the impact of our research and the prevention, diagnosis and treatment of environmental diseases. A major goal is to facilitate productive interactions between basic and applied environmental science. This will be accomplished by fostering active collaborations among six scientific cores: They are: 1) Radiobiology and Environmental Carcinogenesis, 2) Biochemical and Environmental Toxicology, 3) Respiratory Biology and Inhalation Toxicology, 4) Environmental Epidemiology, 5) Occupational Health, and 6) Environmental Science and Engineering. The work of the scientific cores, their faculty, students and fellows, will be greatly facilitated by four facilities cores: They include: 1) Cell and Molecular Imaging, 2) Human Cell Bank, Genotyping and Tissue Culture, 3) Exposures, and 4) Biostatistics and Data Management. Finally our ability to make our research available to the public will be greatly enhanced by our Community Outreach and Education Core. The theme of our center grant is the effects of physical and chemical factors in the environment on biological system, with particular emphasis on the health of humans. Biologic effects include alteration of function, as well as initiation or aggravation of illness, disability and premature death. A wide range of diseases and effects are included, such as cancer, chronic lung disease, reproductive outcomes and effects on the nervous and renal systems. Our approaches are both toxicologic and epidemiologic. Toxicologic approaches include a variety of molecular, biochemical and physiologic methods applied to biologic systems ranging from cells to whole organisms. Epidemiologic methods also cover a wide range from field studies to analysis of vital records and case control studies.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
2P30ES000002-36
Application #
2441797
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
1977-12-01
Project End
2003-03-31
Budget Start
1998-04-01
Budget End
1999-03-31
Support Year
36
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Harvard University
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Li, Wenyuan; Dorans, Kirsten S; Wilker, Elissa H et al. (2018) Ambient air pollution, adipokines, and glucose homeostasis: The Framingham Heart Study. Environ Int 111:14-22
Greenspan, Louise C; Lee, Mary M (2018) Endocrine disrupters and pubertal timing. Curr Opin Endocrinol Diabetes Obes 25:49-54
Mínguez-Alarcón, Lidia; Afeiche, Myriam C; Williams, Paige L et al. (2018) Hair mercury (Hg) levels, fish consumption and semen parameters among men attending a fertility center. Int J Hyg Environ Health 221:174-182
Draz, Mohamed Shehata; Venkataramani, Manasa; Lakshminarayanan, Harini et al. (2018) Nanoparticle-enhanced electrical detection of Zika virus on paper microchips. Nanoscale 10:11841-11849
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Draz, Mohamed Shehata; Moazeni, Maryam; Venkataramani, Manasa et al. (2018) Hybrid Paper-Plastic Microchip for Flexible and High-Performance Point-of-Care Diagnostics. Adv Funct Mater 28:
Lepeule, Johanna; Litonjua, Augusto A; Gasparrini, Antonio et al. (2018) Lung function association with outdoor temperature and relative humidity and its interaction with air pollution in the elderly. Environ Res 165:110-117
Specht, Aaron J; Kponee, Kale; Nkpaa, Kpobari W et al. (2018) Validation of x-ray fluorescence measurements of metals in toenail clippings against inductively coupled plasma mass spectrometry in a Nigerian population. Physiol Meas 39:085007
Gaskins, Audrey J; Hart, Jaime E; Mínguez-Alarcón, Lidia et al. (2018) Residential proximity to major roadways and traffic in relation to outcomes of in vitro fertilization. Environ Int 115:239-246

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