The theme begins with a unique and defining strength of the Harvard-NIEHS Center for Environmental Health, the investigators'unmatched portfolio of population and patient studies of environmental exposures and their health effects. These studies of the real-world environmental exposures of human subjects ensure that Center research readily translates into public health policy and clinical practice. These population-based investigations combine with mechanistic laboratory studies to illuminate the pathways by which environmental exposures cause health effects. The Center makes this partnership a productive """"""""two-way street"""""""": Data from populations inform and guide studies of pathways in animal and cell culture models. In turn, the evidence from pathway studies is used to improve or develop new population studies of exposures and health effects. Together their """"""""Populations to Pathways"""""""" research provides both estimates of human population risk as well as adding to the understanding of mechanistic pathways of environmental health effects. The investigations of populations and pathways in turn inform public health policy and clinical practice. To facilitate interactions the Center is organized around three Research Cores representing major cross-cutting environmental health exposures: Metals, Organic Chemicals, and Particulates. Each of the Research Cores has track record of productivity, potential for continued growth, and the ability to integrate and catalyze leadership in the future. Each Research Core is multidisciplinary and deploys the full range of our intellectual resources. These Research Cores have been highly effective in promoting integration and collaborations through seminars and symposium, invited speakers, working groups, and pilot projects. Each of the three Research Cores features toxicology, basic mechanisms, in vitro models, animal models, gene- environment interactions, epidemiology, risk analysis, risk communication and connects to the Community Outreach and Education Core. Each includes exposure assessment as well as health outcomes in both animal models and human populations. Moreover, each represents an area of considerable activity and accomplishment as well as a compelling list of unsolved concerns. By using the Center mechanism to increase integration, each Research Core is composed of individuals not only from a variety of disciplines, but also from a range of academic programs and departments throughout Harvard and at neighboring institutions. The Community Outreach and Education Core (COEC) provides a community context for the research and integrated health sciences occurring within the Center and supports the Center's goal to translate its research into public health policy and clinical practice, and serves as a conduit for the community and stakeholders to interact with and provide guidance to the Center in defining research priorities and opportunities.

Public Health Relevance

Building on a rich resource of population and clinical studies, the Harvard-NIEHS Center for Environmental Health is applying the best available technologies and methods to population studies, including the riches offered by the omics era to reveal the mechanisms of emerging environmental threats. Through this approach, the research results are immediately translatable to community standards (Healthy neighborhoods), family decisions (Healthy Homes), and personal choices (Healthy People). INSTITUTIONAL COMMITMENT AND ORGANIZATION

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Center Core Grants (P30)
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Environmental Health Sciences Review Committee (EHS)
Program Officer
Reinlib, Leslie J
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Harvard University
Public Health & Prev Medicine
Schools of Public Health
United States
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Hart, Jaime E; Bertrand, Kimberly A; DuPre, Natalie et al. (2018) Exposure to hazardous air pollutants and risk of incident breast cancer in the nurses' health study II. Environ Health 17:28
Raz, Raanan; Kioumourtzoglou, Marianthi-Anna; Weisskopf, Marc G (2018) Live-Birth Bias and Observed Associations Between Air Pollution and Autism. Am J Epidemiol 187:2292-2296
Chiu, Yu-Han; Williams, Paige L; Mínguez-Alarcón, Lidia et al. (2018) Comparison of questionnaire-based estimation of pesticide residue intake from fruits and vegetables with urinary concentrations of pesticide biomarkers. J Expo Sci Environ Epidemiol 28:31-39
James-Todd, Tamarra M; Chiu, Yu-Han; Messerlian, Carmen et al. (2018) Trimester-specific phthalate concentrations and glucose levels among women from a fertility clinic. Environ Health 17:55
Lee, Alison; Leon Hsu, Hsiao-Hsien; Mathilda Chiu, Yueh-Hsiu et al. (2018) Prenatal fine particulate exposure and early childhood asthma: Effect of maternal stress and fetal sex. J Allergy Clin Immunol 141:1880-1886
Gold, Diane R; Zanobetti, Antonella (2018) Do Maternal Air Pollution Exposures Have Long-Lasting Influences on Child Blood Pressure? Hypertension 72:56-58
Guo, Yichen; Zhang, Ruyang; Shen, Sipeng et al. (2018) DNA Methylation of LRRC3B: A Biomarker for Survival of Early-Stage Non-Small Cell Lung Cancer Patients. Cancer Epidemiol Biomarkers Prev 27:1527-1535
Rotem, Ran S; Chodick, Gabriel; Davidovitch, Michael et al. (2018) Congenital Abnormalities of the Male Reproductive System and Risk of Autism Spectrum Disorders. Am J Epidemiol 187:656-663
Antonelli, Joseph; Cefalu, Matthew; Palmer, Nathan et al. (2018) Doubly robust matching estimators for high dimensional confounding adjustment. Biometrics :
Kresovich, Jacob K; Bulka, Catherine M; Joyce, Brian T et al. (2018) The Inflammatory Potential of Dietary Manganese in a Cohort of Elderly Men. Biol Trace Elem Res 183:49-57

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