Abstract

This proposal is for core support for an Environmental Health Sciences Center which has the mission of investigation of the toxicology of environmental chemicals. It involves an interdisciplinary program of research and training on problems of biochemical mechanisms, biological effects, analyses, pharmacodynamic modeling and physicochemical principles and processes in routes of exposure (Chemodynamics). Chemicals to be studied will include heavy metals, synthetic-industrial organics, pesticides, wood preservatives and natural products. The objectives of the program are: 1) To conduct investigations on toxicology of environmental chemicals, the mechanism of action, effects and transport and fate. 2) To provide core support to research staff for environmental health research and specialized projects in analytical chemistry, pathology, and statistical methods. 3) To identify and assess potential problems caused by chemicals in the environment; serve as a resource to other centers and state and federal agencies having environmental health concerns.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES000210-21
Application #
3102233
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
1975-11-01
Project End
1990-11-30
Budget Start
1987-12-01
Budget End
1988-11-30
Support Year
21
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
Oregon State University
Department
Type
Organized Research Units
DUNS #
053599908
City
Corvallis
State
OR
Country
United States
Zip Code
97339

  Publications

Geier, Mitra C; Chlebowski, Anna C; Truong, Lisa et al. (2018) Comparative developmental toxicity of a comprehensive suite of polycyclic aromatic hydrocarbons. Arch Toxicol 92:571-586
Bugel, Sean M; Tanguay, Robert L (2018) Multidimensional chemobehavior analysis of flavonoids and neuroactive compounds in zebrafish. Toxicol Appl Pharmacol 344:23-34
Gaulke, Christopher A; Rolshoven, John; Wong, Carmen P et al. (2018) Marginal Zinc Deficiency and Environmentally Relevant Concentrations of Arsenic Elicit Combined Effects on the Gut Microbiome. mSphere 3:
Roper, Courtney; Simonich, Staci L Massey; Tanguay, Robert L (2018) Development of a high-throughput in vivo screening platform for particulate matter exposures. Environ Pollut 235:993-1005
Haggard, Derik E; Noyes, Pamela D; Waters, Katrina M et al. (2018) Transcriptomic and phenotypic profiling in developing zebrafish exposed to thyroid hormone receptor agonists. Reprod Toxicol 77:80-93
Nix, Cassandra E; Harper, Bryan J; Conner, Cathryn G et al. (2018) Toxicological Assessment of a Lignin Core Nanoparticle Doped with Silver as an Alternative to Conventional Silver Core Nanoparticles. Antibiotics (Basel) 7:
Geier, Mitra C; James Minick, D; Truong, Lisa et al. (2018) Systematic developmental neurotoxicity assessment of a representative PAH Superfund mixture using zebrafish. Toxicol Appl Pharmacol 354:115-125
Welch, Barrett; Smit, Ellen; Cardenas, Andres et al. (2018) Trends in urinary arsenic among the U.S. population by drinking water source: Results from the National Health and Nutritional Examinations Survey 2003-2014. Environ Res 162:8-17
Denluck, Lindsay; Wu, Fan; Crandon, Lauren E et al. (2018) Reactive oxygen species generation is likely a driver of copper based nanomaterial toxicity. Environ Sci Nano 5:1473-1481
Ahn, Soyoun; Magaña, Armando Alcazar; Bozarth, Connie et al. (2018) Integrated identification and quantification of cyanobacterial toxins from Pacific Northwest freshwaters by Liquid Chromatography and High-resolution Mass Spectrometry. J Mex Chem Soc 62:

Showing the most recent 10 out of 690 publications