Abstract

(From the Applicant's Description) The aim of the Structural Biology and Environmental Chemistry Research Core is to initiate and foster research that focuses on understanding the relation between fundamental, structural features of organic molecules and the behaviors of those molecules in environmental and biological systems. The focus of this Core is to: analyze the behavior of organic molecules in the environment; elucidate the site(s) of modification(s) of macromolecules by environmental chemicals; and develop an understanding of the effects of modifications on biopolymer structure and function. Within these areas, current research efforts involve the relationship between surfactant structure and behavior in sewage-contaminated water; the use of mass spectrometry to determine the site(s) and effects of alkylation of neurofilament protein subunits by gamma-diketoalkanes; analysis and effects of thiol alkylation on protein folding pathways of rhm-CSFbeta; and conformational changes in thioredoxin caused by thiol alkylation; and the use of mass spectrometry and X-ray crystallography to map DNA-protein interactions and cross-linked or metal-complexed nucleic acid structures.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
2P30ES000210-34
Application #
6442953
Study Section
Project Start
1975-11-01
Project End
2006-03-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
34
Fiscal Year
2001
Total Cost
$78,870
Indirect Cost

  Institution

Name
Oregon State University
Department
Type
DUNS #
053599908
City
Corvallis
State
OR
Country
United States
Zip Code
97339

  Publications

Nix, Cassandra E; Harper, Bryan J; Conner, Cathryn G et al. (2018) Toxicological Assessment of a Lignin Core Nanoparticle Doped with Silver as an Alternative to Conventional Silver Core Nanoparticles. Antibiotics (Basel) 7:
Geier, Mitra C; James Minick, D; Truong, Lisa et al. (2018) Systematic developmental neurotoxicity assessment of a representative PAH Superfund mixture using zebrafish. Toxicol Appl Pharmacol 354:115-125
Welch, Barrett; Smit, Ellen; Cardenas, Andres et al. (2018) Trends in urinary arsenic among the U.S. population by drinking water source: Results from the National Health and Nutritional Examinations Survey 2003-2014. Environ Res 162:8-17
Denluck, Lindsay; Wu, Fan; Crandon, Lauren E et al. (2018) Reactive oxygen species generation is likely a driver of copper based nanomaterial toxicity. Environ Sci Nano 5:1473-1481
Ahn, Soyoun; Magaña, Armando Alcazar; Bozarth, Connie et al. (2018) Integrated identification and quantification of cyanobacterial toxins from Pacific Northwest freshwaters by Liquid Chromatography and High-resolution Mass Spectrometry. J Mex Chem Soc 62:
Titaley, Ivan A; Ogba, O Maduka; Chibwe, Leah et al. (2018) Automating data analysis for two-dimensional gas chromatography/time-of-flight mass spectrometry non-targeted analysis of comparative samples. J Chromatogr A 1541:57-62
Geier, Mitra C; Chlebowski, Anna C; Truong, Lisa et al. (2018) Comparative developmental toxicity of a comprehensive suite of polycyclic aromatic hydrocarbons. Arch Toxicol 92:571-586
Bugel, Sean M; Tanguay, Robert L (2018) Multidimensional chemobehavior analysis of flavonoids and neuroactive compounds in zebrafish. Toxicol Appl Pharmacol 344:23-34
Gaulke, Christopher A; Rolshoven, John; Wong, Carmen P et al. (2018) Marginal Zinc Deficiency and Environmentally Relevant Concentrations of Arsenic Elicit Combined Effects on the Gut Microbiome. mSphere 3:
Roper, Courtney; Simonich, Staci L Massey; Tanguay, Robert L (2018) Development of a high-throughput in vivo screening platform for particulate matter exposures. Environ Pollut 235:993-1005

Showing the most recent 10 out of 690 publications