Abstract

Original Goals and Specific Aims The Aquatic Models Core is a unique facility worldwide, equipped to conduct biomedical research using two of the most powerful aquatic research models -- rainbow trout and zebrafish. It is a self-contained fish hatchery for rearing fish and a histopathology complex for conducting tumor and toxicity studies. For the carcinogenesis and toxicity studies, investigators can choose several exposure routes, such as water-bath exposure of embryos or fry, dietary exposure, or embryo injection. The goal is to facilitate the short- and long-term experiments of Center investigators in several research cores by: ? Providing consultation to establish the suitability and feasibility of conducting studies in aquatic models; ? Providing high quality rainbow trout and zebrafish at multiple life stages; ? Providing technical core support including tank allocations, diet preparation and feeding; ? Providing assistance in selecting and performing chemical exposures; ? Providing specific expertise in surgery, necropsy, and histopathological evaluation; ? Working with the investigators in data acquisition and interpretation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES000210-40
Application #
7596386
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
2008-04-01
Budget End
2009-03-31
Support Year
40
Fiscal Year
2008
Total Cost
$250,414
Indirect Cost

  Institution

Name
Oregon State University
Department
Type
DUNS #
053599908
City
Corvallis
State
OR
Country
United States
Zip Code
97339

  Publications

Geier, Mitra C; Chlebowski, Anna C; Truong, Lisa et al. (2018) Comparative developmental toxicity of a comprehensive suite of polycyclic aromatic hydrocarbons. Arch Toxicol 92:571-586
Bugel, Sean M; Tanguay, Robert L (2018) Multidimensional chemobehavior analysis of flavonoids and neuroactive compounds in zebrafish. Toxicol Appl Pharmacol 344:23-34
Gaulke, Christopher A; Rolshoven, John; Wong, Carmen P et al. (2018) Marginal Zinc Deficiency and Environmentally Relevant Concentrations of Arsenic Elicit Combined Effects on the Gut Microbiome. mSphere 3:
Roper, Courtney; Simonich, Staci L Massey; Tanguay, Robert L (2018) Development of a high-throughput in vivo screening platform for particulate matter exposures. Environ Pollut 235:993-1005
Haggard, Derik E; Noyes, Pamela D; Waters, Katrina M et al. (2018) Transcriptomic and phenotypic profiling in developing zebrafish exposed to thyroid hormone receptor agonists. Reprod Toxicol 77:80-93
Nix, Cassandra E; Harper, Bryan J; Conner, Cathryn G et al. (2018) Toxicological Assessment of a Lignin Core Nanoparticle Doped with Silver as an Alternative to Conventional Silver Core Nanoparticles. Antibiotics (Basel) 7:
Geier, Mitra C; James Minick, D; Truong, Lisa et al. (2018) Systematic developmental neurotoxicity assessment of a representative PAH Superfund mixture using zebrafish. Toxicol Appl Pharmacol 354:115-125
Welch, Barrett; Smit, Ellen; Cardenas, Andres et al. (2018) Trends in urinary arsenic among the U.S. population by drinking water source: Results from the National Health and Nutritional Examinations Survey 2003-2014. Environ Res 162:8-17
Denluck, Lindsay; Wu, Fan; Crandon, Lauren E et al. (2018) Reactive oxygen species generation is likely a driver of copper based nanomaterial toxicity. Environ Sci Nano 5:1473-1481
Ahn, Soyoun; Magaña, Armando Alcazar; Bozarth, Connie et al. (2018) Integrated identification and quantification of cyanobacterial toxins from Pacific Northwest freshwaters by Liquid Chromatography and High-resolution Mass Spectrometry. J Mex Chem Soc 62:

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