The Center grant provides resources to support six program areas: 1) Human Exposure and Health Effects; 2) Epidemiology; 3) Environmental and Occupational Medicine; 4) Systemic Toxicology; 5) Environmental Carcinogenesis; and 6) Molecular and Genetic Toxicology. A major emphasis of the Center continues to be the study of environmental factors that affect human disease and disease exacerbations, as well as the development of methods for detection, prevention and control of environmentally related diseases. To tackle this vast array of problems, the Center has brought together and integrated the efforts of a multidisciplinary group of established scientists who are building on the resources of New York University Medical Center and the University community at large. In particular, research strengths at the institute include: l) DNA adducts, chemistry, mutagenesis; 2) metal toxicology and carcinogenesis; 3) oncogenes and tumor suppressor genes; 4) oxidative damage and chemoprevention; 5) radiation bioeffects; 6) biomarkers of exposure, response and susceptibility; 7) effects of ambient air pollutant exposures on lung structure function and disease progression; and 8) particle deposition and clearance from the lungs.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES000260-37
Application #
2900375
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Collman, Gwen W
Project Start
1975-01-01
Project End
2000-03-31
Budget Start
1999-04-01
Budget End
2000-03-31
Support Year
37
Fiscal Year
1999
Total Cost
Indirect Cost
Name
New York University
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10016
Roy, Nirmal K; Candelmo, Allison; DellaTorre, Melissa et al. (2018) Characterization of AHR2 and CYP1A expression in Atlantic sturgeon and shortnose sturgeon treated with coplanar PCBs and TCDD. Aquat Toxicol 197:19-31
Klocke, Carolyn; Allen, Joshua L; Sobolewski, Marissa et al. (2018) Exposure to fine and ultrafine particulate matter during gestation alters postnatal oligodendrocyte maturation, proliferation capacity, and myelination. Neurotoxicology 65:196-206
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Roy, Nirmal K; DellaTorre, Melissa; Candelmo, Allison et al. (2018) Characterization of AHR1 and its functional activity in Atlantic sturgeon and shortnose sturgeon. Aquat Toxicol 205:25-35
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Church, Jamie S; Tijerina, Pamella B; Emerson, Felicity J et al. (2018) Perinatal exposure to concentrated ambient particulates results in autism-like behavioral deficits in adult mice. Neurotoxicology 65:231-240
Jin, Honglei; Sun, Wenrui; Zhang, Yuanmei et al. (2018) MicroRNA-411 Downregulation Enhances Tumor Growth by Upregulating MLLT11 Expression in Human Bladder Cancer. Mol Ther Nucleic Acids 11:312-322
Chen, Danqi; Fang, Lei; Li, Hongjie et al. (2018) The effects of acetaldehyde exposure on histone modifications and chromatin structure in human lung bronchial epithelial cells. Environ Mol Mutagen 59:375-385

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