Abstract

The overall goal of the IHSFC is to facilitate both patient-oriented and population-based research directed at studies of the etiology, pathogenesis, and prognosis of disease in patient populations, and to integrate this work with the strong basic science programs within the Center in Molecular Toxicology.
Aim 1. To stimulate and support both clinical and translational research, including patient-oriented and population-based research, within the Vanderbilt P30 EHS Core Center by expanding existing research projects and fostering new interdisciplinary activities focusing on environmental health problems.
Aim 2. To describe the development process, infrastructure and outcomes of the IHFSC in order to not only create, but optimize and be a successful example of developing a core infrastructure and environment for interdisciplinary science both for the purposes of conducting interdisciplinary research, as well as for training new interdisciplinary scientists both among the ranks of established investigators, as well as among trainees.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES000267-45
Application #
8377581
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
45
Fiscal Year
2012
Total Cost
$337,846
Indirect Cost
$147,783

  Institution

Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212

  Publications

Wages, Phillip A; Kim, Hye-Young H; Korade, Zeljka et al. (2018) Identification and characterization of prescription drugs that change levels of 7-dehydrocholesterol and desmosterol. J Lipid Res 59:1916-1926
Neely, M Diana; Davison, Carrie Ann; Aschner, Michael et al. (2017) From the Cover: Manganese and Rotenone-Induced Oxidative Stress Signatures Differ in iPSC-Derived Human Dopamine Neurons. Toxicol Sci 159:366-379
Sha, Yan; Minko, Irina G; Malik, Chanchal K et al. (2017) Error-prone replication bypass of the imidazole ring-opened formamidopyrimidine deoxyguanosine adduct. Environ Mol Mutagen 58:182-189
Sugitani, Norie; Voehler, Markus W; Roh, Michelle S et al. (2017) Analysis of DNA binding by human factor xeroderma pigmentosum complementation group A (XPA) provides insight into its interactions with nucleotide excision repair substrates. J Biol Chem 292:16847-16857
Minko, Irina G; Rizzo, Carmelo J; Lloyd, R Stephen (2017) Mutagenic potential of nitrogen mustard-induced formamidopyrimidine DNA adduct: Contribution of the non-canonical ?-anomer. J Biol Chem 292:18790-18799
Rivara, Matthew B; Yeung, Catherine K; Robinson-Cohen, Cassianne et al. (2017) Effect of Coenzyme Q10 on Biomarkers of Oxidative Stress and Cardiac Function in Hemodialysis Patients: The CoQ10 Biomarker Trial. Am J Kidney Dis 69:389-399
Yan, H P; Roberts, L J; Davies, S S et al. (2017) Isolevuglandins as a gauge of lipid peroxidation in human tumors. Free Radic Biol Med 106:62-68
Lin, Ying-Chih; Owen, Nichole; Minko, Irina G et al. (2016) DNA polymerase ? limits chromosomal damage and promotes cell survival following aflatoxin exposure. Proc Natl Acad Sci U S A 113:13774-13779
Shimada, Tsutomu; Takenaka, Shigeo; Kakimoto, Kensaku et al. (2016) Structure-Function Studies of Naphthalene, Phenanthrene, Biphenyl, and Their Derivatives in Interaction with and Oxidation by Cytochromes P450 2A13 and 2A6. Chem Res Toxicol 29:1029-40
Bose, Arindam; Millsap, Amy D; DeLeon, Arnie et al. (2016) Translesion Synthesis of the N(2)-2'-Deoxyguanosine Adduct of the Dietary Mutagen IQ in Human Cells: Error-Free Replication by DNA Polymerase ? and Mutagenic Bypass by DNA Polymerases ?, ?, and Rev1. Chem Res Toxicol 29:1549-59

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