The overarching goals of our Environmental Health Sciences Center (EHSC) are to prevent disease and improve public health through innovative programs of excellence in environmental health sciences research, to engage communities to address environmental health issues, and to enhance career development of talented environmental health investigators. The EHSC provides the framework for the generation of novel research findings and their conversion into effective resources for public health officials, medical professionals, and the community. This tradition of success is based on our ability to recruit broad multi- and interdisciplinary expertis, maintain a strong emphasis on basic science principles while incorporating clinical and translational approaches, and effectively interact with the community. The specific mission of the EHSC at Rochester is to improve public health through the generation of fundamental knowledge and elaboration of mechanisms by which chemical exposures, alone or through interaction with other modifying factors, contribute to cumulative health risk across the life span As such, the theme that guides and integrates EHSC research and community engagement programs is the understanding of interactions of environmental and occupational agents with diverse individual contexts across the lifespan in modulating human disease and dysfunction. The goals of the Center are achieved through a major focus on three research programs: Pulmonary & Cardiovascular Disease Program, Neurodevelopmental & Neurodegenerative Disease Program, and Musculoskeletal Disease Program. While the Center is structurally organized into these Disease Programs, shared thematic biological processes, including immunological responses & inflammation, stem cell biology, early life sensitivities and mechanisms of adult disease, epigenetics, and nutritional/dietary factors, weave these programs together and synergize the research. These research efforts are supported by several structural units: Administrative Core, Integrative Health Sciences Facility Core, Biostatistics Facility Core, Community Outreach & Engagement Core, Pilot Project Program, and Career Development Program for Environmental Health Science Investigators.

Public Health Relevance

The mission of the EHSC at Rochester is to improve public health through the generation of fundamental knowledge and elaboration of mechanisms by which chemical exposures, alone or through interaction with other modifying factors, contribute to cumulative health risk across the lifespan. This mission is achieved by the integration of basic science with clinical research, and the translation of this research through community engagement, education and prevention. The EHSC provides the framework for the generation of novel research findings and their conversion into effective resources for public health official, medical professionals, and the community.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
3P30ES001247-45S1
Application #
10085019
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Thompson, Claudia L
Project Start
1997-04-27
Project End
2021-03-31
Budget Start
2020-03-01
Budget End
2020-03-31
Support Year
45
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Rochester
Department
Public Health & Prev Medicine
Type
School of Medicine & Dentistry
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627
Sobolewski, Marissa; Conrad, Katherine; Marvin, Elena et al. (2018) Endocrine active metals, prenatal stress and enhanced neurobehavioral disruption. Horm Behav 101:36-49
Klocke, Carolyn; Allen, Joshua L; Sobolewski, Marissa et al. (2018) Exposure to fine and ultrafine particulate matter during gestation alters postnatal oligodendrocyte maturation, proliferation capacity, and myelination. Neurotoxicology 65:196-206
McSorley, Emeir M; Yeates, Alison J; Mulhern, Maria S et al. (2018) Associations of maternal immune response with MeHg exposure at 28 weeks' gestation in the Seychelles Child Development Study. Am J Reprod Immunol 80:e13046
Duffney, Parker F; Falsetta, Megan L; Rackow, Ashley R et al. (2018) Key roles for lipid mediators in the adaptive immune response. J Clin Invest 128:2724-2731
Morris-Schaffer, Keith; Sobolewski, Marissa; Allen, Joshua L et al. (2018) Effect of neonatal hyperoxia followed by concentrated ambient ultrafine particle exposure on cumulative learning in C57Bl/6J mice. Neurotoxicology 67:234-244
Willis, Mary D; Jusko, Todd A; Halterman, Jill S et al. (2018) Unconventional natural gas development and pediatric asthma hospitalizations in Pennsylvania. Environ Res 166:402-408
Wahlberg, Karin; Love, Tanzy M; Pineda, Daniela et al. (2018) Maternal polymorphisms in glutathione-related genes are associated with maternal mercury concentrations and early child neurodevelopment in a population with a fish-rich diet. Environ Int 115:142-149
Cholette, Jill M; Pietropaoli, Anthony P; Henrichs, Kelly F et al. (2018) Elevated free hemoglobin and decreased haptoglobin levels are associated with adverse clinical outcomes, unfavorable physiologic measures, and altered inflammatory markers in pediatric cardiac surgery patients. Transfusion 58:1631-1639
Boule, Lisbeth A; Burke, Catherine G; Jin, Guang-Bi et al. (2018) Aryl hydrocarbon receptor signaling modulates antiviral immune responses: ligand metabolism rather than chemical source is the stronger predictor of outcome. Sci Rep 8:1826
Lacy, Shannon H; Woeller, Collynn F; Thatcher, Thomas H et al. (2018) Activated Human Lung Fibroblasts Produce Extracellular Vesicles with Anti-Fibrotic Prostaglandins. Am J Respir Cell Mol Biol :

Showing the most recent 10 out of 556 publications