Abstract

This freshwater biomedical center will synergize with the research activities of investigators at the Medical College of Wisconsin and the University of Wisconsin. The center will service investigators involved in biomedical-environmental research and coordinate and foster interdisciplinary research related to the interaction of environmental chemicals with biological systems. The center will provide animals, space, supplies and technical support for biomedical scientists with ongoing research programs who have the desire to pursue studies related to the use of aquatic species as models in disease processes or to the understanding of the mechanism of toxic interactions of chemicals in aquatic species. Although not a primary objective, research done at the center may provide baseline data to be used in the development of models using lower life forms in biomedical research.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES001985-08
Application #
3102311
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
1978-09-29
Project End
1987-06-30
Budget Start
1986-07-01
Budget End
1987-06-30
Support Year
8
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Medical College of Wisconsin
Department
Type
Schools of Medicine
DUNS #
073134603
City
Milwaukee
State
WI
Country
United States
Zip Code
53226

  Publications

Jensen, Brigid K; Monnerie, Hubert; Mannell, Maggie V et al. (2015) Altered Oligodendrocyte Maturation and Myelin Maintenance: The Role of Antiretrovirals in HIV-Associated Neurocognitive Disorders. J Neuropathol Exp Neurol 74:1093-118
Kleinow, K M; Haasch, M L; Williams, D E et al. (1990) A comparison of hepatic P450 induction in rat and trout (Oncorhynchus mykiss): delineation of the site of resistance of fish to phenobarbital-type inducers. Comp Biochem Physiol C 96:259-70
Haasch, M L; Wejksnora, P J; Stegeman, J J et al. (1989) Cloned rainbow trout liver P(1)450 complementary DNA as a potential environmental monitor. Toxicol Appl Pharmacol 98:362-8
Spitsbergen, J M; Kleeman, J M; Peterson, R E (1988) 2,3,7,8-Tetrachlorodibenzo-p-dioxin toxicity in yellow perch (Perca flavescens). J Toxicol Environ Health 23:359-83
Erickson, D A; Goodrich, M S; Lech, J J (1988) The effect of piperonyl butoxide on hepatic cytochrome P-450-dependent monooxygenase activities in rainbow trout (Salmo gairdneri). Toxicol Appl Pharmacol 94:1-10
Haasch, M L; Kleinow, K M; Lech, J J (1988) Induction of cytochrome P-450 mRNA in rainbow trout: in vitro translation and immunodetection. Toxicol Appl Pharmacol 94:246-53
Kleeman, J M; Olson, J R; Peterson, R E (1988) Species differences in 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity and biotransformation in fish. Fundam Appl Toxicol 10:206-13
Spitsbergen, J M; Kleeman, J M; Peterson, R E (1988) Morphologic lesions and acute toxicity in rainbow trout (Salmo gairdneri) treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Toxicol Environ Health 23:333-58
Kleinow, K M; Melancon, M J; Lech, J J (1987) Biotransformation and induction: implications for toxicity, bioaccumulation and monitoring of environmental xenobiotics in fish. Environ Health Perspect 71:105-19
Yee, R W; Edelhauser, H F; Stern, M E (1987) Specular microscopy of vertebrate corneal endothelium: a comparative study. Exp Eye Res 44:703-14

Showing the most recent 10 out of 25 publications