Abstract

The Mutation and Cancer Research Core was created to address the relationships between DNA damage, DNA repair, mutation and cancer associated with exposure to environmental and endogenous chemical and physical agents. One of the central questions here is the degree to which environmental and endogenous processes contribute to the mutational burdcn of human cells.
The Specific Aims of this Core are: (1) To further the development of Center research projects and programs that address the mechanistic linkages between exposure to environmental and endogenous agents, genetic change and cancer, and other diseases. (2) To promote interaction among the members of the Mutation and Cancer Research Core, and interactions between members of this Research Core and those of the other two Research Cores, with the goal of creating new research projects and programs. (3) To promote the development and acquisition of new technologies in the CEHS Facilities Cores that will facilitate studies in the Mutation and Cancer Research Core.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES002109-29
Application #
7600604
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
2008-04-01
Budget End
2009-03-31
Support Year
29
Fiscal Year
2008
Total Cost
$7,658
Indirect Cost

  Institution

Name
Massachusetts Institute of Technology
Department
Type
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02139

  Publications

Wong, Madeline Y; Chen, Kenny; Antonopoulos, Aristotelis et al. (2018) XBP1s activation can globally remodel N-glycan structure distribution patterns. Proc Natl Acad Sci U S A 115:E10089-E10098
Hadley, Rose C; Gagnon, Derek M; Brophy, Megan Brunjes et al. (2018) Biochemical and Spectroscopic Observation of Mn(II) Sequestration from Bacterial Mn(II) Transport Machinery by Calprotectin. J Am Chem Soc 140:110-113
Lieberman, Mia T; Van Tyne, Daria; Dzink-Fox, JoAnn et al. (2018) Long-Term Colonization Dynamics of Enterococcus faecalis in Implanted Devices in Research Macaques. Appl Environ Microbiol 84:
Wadduwage, Dushan N; Kay, Jennifer; Singh, Vijay Raj et al. (2018) Automated fluorescence intensity and gradient analysis enables detection of rare fluorescent mutant cells deep within the tissue of RaDR mice. Sci Rep 8:12108
Jackson, Megan N; Oh, Seokjoon; Kaminsky, Corey J et al. (2018) Strong Electronic Coupling of Molecular Sites to Graphitic Electrodes via Pyrazine Conjugation. J Am Chem Soc 140:1004-1010
Chen, Percival Yang-Ting; Funk, Michael A; Brignole, Edward J et al. (2018) Disruption of an oligomeric interface prevents allosteric inhibition of Escherichia coli class Ia ribonucleotide reductase. J Biol Chem 293:10404-10412
Lieberman, Mia T; Madden, Carolyn M; Ma, Eric J et al. (2018) Evaluation of 6 Methods for Aerobic Bacterial Sanitization of Smartphones. J Am Assoc Lab Anim Sci 57:24-29
Edington, Collin D; Chen, Wen Li Kelly; Geishecker, Emily et al. (2018) Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies. Sci Rep 8:4530
Mannion, Anthony; Shen, Zeli; Feng, Yan et al. (2018) Gamma-glutamyltranspeptidase expression by Helicobacter saguini, an enterohepatic Helicobacter species isolated from cotton top tamarins with chronic colitis. Cell Microbiol :e12968
Tajai, Preechaya; Fedeles, Bogdan I; Suriyo, Tawit et al. (2018) An engineered cell line lacking OGG1 and MUTYH glycosylases implicates the accumulation of genomic 8-oxoguanine as the basis for paraquat mutagenicity. Free Radic Biol Med 116:64-72

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