Abstract

The Mutation and Cancer Research Core was created to address the relationships between DNA damage, DNA repair, mutation and cancer associated with exposure to environmental and endogenous chemical and physical agents. One of the central questions here is the degree to which environmental and endogenous processes contribute to the mutational burdcn of human cells.
The Specific Aims of this Core are: (1) To further the development of Center research projects and programs that address the mechanistic linkages between exposure to environmental and endogenous agents, genetic change and cancer, and other diseases. (2) To promote interaction among the members of the Mutation and Cancer Research Core, and interactions between members of this Research Core and those of the other two Research Cores, with the goal of creating new research projects and programs. (3) To promote the development and acquisition of new technologies in the CEHS Facilities Cores that will facilitate studies in the Mutation and Cancer Research Core.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES002109-30
Application #
7798627
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
2009-04-01
Budget End
2010-03-31
Support Year
30
Fiscal Year
2009
Total Cost
$9,191
Indirect Cost

  Institution

Name
Massachusetts Institute of Technology
Department
Type
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02139

  Publications

Tajai, Preechaya; Fedeles, Bogdan I; Suriyo, Tawit et al. (2018) An engineered cell line lacking OGG1 and MUTYH glycosylases implicates the accumulation of genomic 8-oxoguanine as the basis for paraquat mutagenicity. Free Radic Biol Med 116:64-72
Neumann, Wilma; Nolan, Elizabeth M (2018) Evaluation of a reducible disulfide linker for siderophore-mediated delivery of antibiotics. J Biol Inorg Chem 23:1025-1036
Pereira, Gavin C; Sanchez, Laura; Schaughency, Paul M et al. (2018) Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis. Mob DNA 9:35
Wang, Lianrong; Jiang, Susu; Deng, Zixin et al. (2018) DNA phosphorothioate modification - a new multi-functional epigenetic system in bacteria. FEMS Microbiol Rev :
Rothenberg, Daniel A; Taliaferro, J Matthew; Huber, Sabrina M et al. (2018) A Proteomics Approach to Profiling the Temporal Translational Response to Stress and Growth. iScience 9:367-381
Brody, Yehuda; Kimmerling, Robert J; Maruvka, Yosef E et al. (2018) Quantification of somatic mutation flow across individual cell division events by lineage sequencing. Genome Res 28:1901-1918
Freedman, Adam J E; Peet, Kyle C; Boock, Jason T et al. (2018) Isolation, Development, and Genomic Analysis of Bacillus megaterium SR7 for Growth and Metabolite Production Under Supercritical Carbon Dioxide. Front Microbiol 9:2152
Dudani, Jaideep S; Ibrahim, Maria; Kirkpatrick, Jesse et al. (2018) Classification of prostate cancer using a protease activity nanosensor library. Proc Natl Acad Sci U S A 115:8954-8959
Nakashige, Toshiki G; Bowman, Sarah E J; Zygiel, Emily M et al. (2018) Biophysical Examination of the Calcium-Modulated Nickel-Binding Properties of Human Calprotectin Reveals Conformational Change in the EF-Hand Domains and His3Asp Site. Biochemistry 57:4155-4164
Ganesh, B P; Hall, A; Ayyaswamy, S et al. (2018) Diacylglycerol kinase synthesized by commensal Lactobacillus reuteri diminishes protein kinase C phosphorylation and histamine-mediated signaling in the mammalian intestinal epithelium. Mucosal Immunol 11:380-393

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