Abstract

The overall objective of the Animal Models Facilities Core (AMFC) is to provide Center members with state-of-the-art pathology support, transgenic resources and a centrally managed AAALAC-approved animal resource and surgical facility. The Core is staffed with experienced personnel and is equipped with essential equipment to generate genetically engineered mice, rederive imported mice by embryo transfer rederivation, provide colony management, develop surgical models and prepare and interpret tissue samples by histological and immunohistochemistry analysis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
2P30ES002109-31A1
Application #
8249291
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
2011-04-15
Budget End
2012-03-31
Support Year
31
Fiscal Year
2011
Total Cost
$237,758
Indirect Cost

  Institution

Name
Massachusetts Institute of Technology
Department
Type
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02139

  Publications

Richardson, Christopher E R; Cunden, Lisa S; Butty, Vincent L et al. (2018) A Method for Selective Depletion of Zn(II) Ions from Complex Biological Media and Evaluation of Cellular Consequences of Zn(II) Deficiency. J Am Chem Soc 140:2413-2416
Hagen, Susan J; Ang, Lay-Hong; Zheng, Yi et al. (2018) Loss of Tight Junction Protein Claudin 18 Promotes Progressive Neoplasia Development in Mouse Stomach. Gastroenterology 155:1852-1867
Viswanathan, Srinivas R; Nogueira, Marina F; Buss, Colin G et al. (2018) Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer. Nat Genet 50:937-943
Co, Julia Y; Cárcamo-Oyarce, Gerardo; Billings, Nicole et al. (2018) Mucins trigger dispersal of Pseudomonas aeruginosa biofilms. NPJ Biofilms Microbiomes 4:23
Winn, Caroline Bodi; Artim, Stephen C; Jamiel, Morgan S et al. (2018) Lung Lobe Torsion in an Adult Male Common Marmoset (Callithrix jacchus). Comp Med 68:314-318
DiChiara, Andrew S; Li, Rasia C; Suen, Patreece H et al. (2018) A cysteine-based molecular code informs collagen C-propeptide assembly. Nat Commun 9:4206
Keegan, Caroline; Krutzik, Stephan; Schenk, Mirjam et al. (2018) Mycobacterium tuberculosis Transfer RNA Induces IL-12p70 via Synergistic Activation of Pattern Recognition Receptors within a Cell Network. J Immunol 200:3244-3258
Phillips, Angela M; Doud, Michael B; Gonzalez, Luna O et al. (2018) Enhanced ER proteostasis and temperature differentially impact the mutational tolerance of influenza hemagglutinin. Elife 7:
Caron, Tyler J; Artim, Stephen C; Israelsen, William J et al. (2018) Cutaneous Dermatophilosis in a Meadow Jumping Mouse (Zapus hudsonius). Comp Med 68:25-30
Moore, Christopher L; Papa 3rd, Louis J; Shoulders, Matthew D (2018) A Processive Protein Chimera Introduces Mutations across Defined DNA Regions In Vivo. J Am Chem Soc 140:11560-11564

Showing the most recent 10 out of 970 publications