A. Objectives, Rationale and Specific Aims The primary purpose of the Exposure Assessment Facility Core is to enhance the research capabilities of Center for Environmental Health in Northern Manhattan (CEHNM) investigators by providing expertise in a number of related activities and services not available elsewhere in the University, including exposure design, method development, sampling and analysis. This Facility Core supports the development and implementation of exposure assessments in support of funded research, pilot studies, new research initiatives, and outreach activities of the CEHNM by coordinating the following services and activities: ? study design, methods development, design and development of new sampling equipment, air sampling, and analytical capabilities; ? expansion of these facilities and efforts in ways that support the evolving strategic goals of the CEHNM; . ? training and mentoring of staff, students and researchers; ? responding to exposure emergencies; ? responding to the needs of the Community Outreach and Education Core (COEC) and local community ograniziations in a number of ways, including testifying in public hearings and carrying out pilot field work to test whether perceived sources of air pollution exist and can be documented. This Facility Core combines analytical capabilities and expertise at the Mailman School of Public Health (MSPH) and Lamont-Doherty Earth Observatory (LDEO). The primary focus of the Exposure Assessment Facility Core is on sampling and analysis of environmental rather than biological samples. The analysis of biomarkers of exposure are addressed by the Trace Metals Facility Core and the Integrative Health Sciences Facility Core, with the exception of lead isotope ratios in blood, which are analyzed at LDEO. A major strength of the CEHNM is the multiple working groups that are developing new initiatives and projects. Members of the Exposure Core participate in many of these groups to assist in the design of new exposure methods and markers that address specific research goals.
The Specific Aims of the Exposure Assessment Facility Core are as follows:
Specific Aim 1 : To provide an infrastructure to assist CEHNM members and Pilot Project awardees carry out human studies of environmental exposures. The core will provide assistance in: a) Exposure assessment study designs;b) Design and development of new samplers;c) Development of analytical methods;d) Analysis of environmental samples for mass, black carbon, trace elements, isotope ratios, allergens, molds, gas concentrations, and trace organics);and e) Lending of monitoring equipment.
Specific Aim 2 : To provide mentoring and training to CEHNM members, students and postdoctoral fellows, and community partners.
|Soneja, Sutyajeet I; Tielsch, James M; Khatry, Subarna K et al. (2017) Characterizing Particulate Matter Exfiltration Estimates for Alternative Cookstoves in a Village-Like Household in Rural Nepal. Environ Manage 60:797-808|
|Williams, D' Ann L; McCormack, Meredith C; Matsui, Elizabeth C et al. (2016) Cow allergen (Bos d2) and endotoxin concentrations are higher in the settled dust of homes proximate to industrial-scale dairy operations. J Expo Sci Environ Epidemiol 26:42-7|
|Bose, S; Rivera-Mariani, F; Chen, R et al. (2016) Domestic exposure to endotoxin and respiratory morbidity in former smokers with COPD. Indoor Air 26:734-42|
|Soneja, Sutyajeet I; Tielsch, James M; Khatry, Subarna K et al. (2016) Highlighting Uncertainty and Recommendations for Improvement of Black Carbon Biomass Fuel-Based Emission Inventories in the Indo-Gangetic Plain Region. Curr Environ Health Rep 3:73-80|
|Kuo, Chin-Chi; Howard, Barbara V; Umans, Jason G et al. (2015) Arsenic Exposure, Arsenic Metabolism, and Incident Diabetes in the Strong Heart Study. Diabetes Care 38:620-7|
|Techapiesancharoenkij, Nirachara; Fiala, Jeannette L A; Navasumrit, Panida et al. (2015) Sulforaphane, a cancer chemopreventive agent, induces pathways associated with membrane biosynthesis in response to tissue damage by aflatoxin B1. Toxicol Appl Pharmacol 282:52-60|
|Vaz, Michelle; Rajasekaran, Subbiah; Potteti, Haranatha R et al. (2015) Myeloid-specific Fos-related antigen-1 regulates cigarette smoke-induced lung inflammation, not emphysema, in mice. Am J Respir Cell Mol Biol 53:125-34|
|Chawanthayatham, Supawadee; Thiantanawat, Apinya; Egner, Patricia A et al. (2015) Prenatal exposure of mice to the human liver carcinogen aflatoxin B1 reveals a critical window of susceptibility to genetic change. Int J Cancer 136:1254-62|
|Peng, Roger D; Butz, Arlene M; Hackstadt, Amber J et al. (2015) Estimating the health benefit of reducing indoor air pollution in a randomized environmental intervention. J R Stat Soc Ser A Stat Soc 178:425-443|
|Ojo, Kristen D; Soneja, Sutyajeet I; Scrafford, Carolyn G et al. (2015) Indoor Particulate Matter Concentration, Water Boiling Time, and Fuel Use of Selected Alternative Cookstoves in a Home-Like Setting in Rural Nepal. Int J Environ Res Public Health 12:7558-81|
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