Abstract

The aim of this Center is to facilitate investigator, graduate student, and postdoctoral research activities that develop and apply unique features of trout and other fish models to problems of biomedical concern. Our focus is on carcinogenesis, immunotoxicity, neurotoxicity, and their modulation by dietary and environmental factors. Center Investigators bring together multidisciplinary expertise in tumor histopathology, statistics, genetics, enzymology, protein chemistry, cell biology, neurobiology, immunology, pharmacology, biophysics, and molecular biology. Though emphasis will remain on basic mechanistic research, our findings have had clinical application at the national level and environmental application at the regional and local levels.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
2P30ES003850-10
Application #
2153468
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
1985-09-27
Project End
1999-03-31
Budget Start
1994-04-01
Budget End
1995-03-31
Support Year
10
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
Oregon State University
Department
Type
Organized Research Units
DUNS #
053599908
City
Corvallis
State
OR
Country
United States
Zip Code
97339

  Publications

Harper, Bryan J; Clendaniel, Alicea; Sinche, Federico et al. (2016) Impacts of chemical modification on the toxicity of diverse nanocellulose materials to developing zebrafish. Cellulose (Lond) 23:1763-1775
Pettersson, B M Fredrik; Das, Sarbashis; Behra, Phani Rama Krishna et al. (2015) Comparative Sigma Factor-mRNA Levels in Mycobacterium marinum under Stress Conditions and during Host Infection. PLoS One 10:e0139823
Qin, Min; Landriscina, Angelo; Rosen, Jamie M et al. (2015) Nitric Oxide-Releasing Nanoparticles Prevent Propionibacterium acnes-Induced Inflammation by Both Clearing the Organism and Inhibiting Microbial Stimulation of the Innate Immune Response. J Invest Dermatol 135:2723-2731
Mordorski, Breanne; Pelgrift, Robert; Adler, Brandon et al. (2015) S-nitrosocaptopril nanoparticles as nitric oxide-liberating and transnitrosylating anti-infective technology. Nanomedicine 11:283-91
Cooper, T K; Murray, K N; Spagnoli, S et al. (2015) Primary intestinal and vertebral chordomas in laboratory zebrafish (Danio rerio). Vet Pathol 52:388-92
Pryor, Joseph B; Harper, Bryan J; Harper, Stacey L (2014) Comparative toxicological assessment of PAMAM and thiophosphoryl dendrimers using embryonic zebrafish. Int J Nanomedicine 9:1947-56
Harper, Bryan; Sinche, Federico; Wu, Rosina Ho et al. (2014) The Impact of Surface Ligands and Synthesis Method on the Toxicity of Glutathione-Coated Gold Nanoparticles. Nanomaterials (Basel) 4:355-371
Park, Kwangsik; Tuttle, George; Sinche, Federico et al. (2013) Stability of citrate-capped silver nanoparticles in exposure media and their effects on the development of embryonic zebrafish (Danio rerio). Arch Pharm Res 36:125-33
Liu, Xiong; Tang, Kaizhi; Harper, Stacey et al. (2013) Predictive modeling of nanomaterial exposure effects in biological systems. Int J Nanomedicine 8 Suppl 1:31-43
Thomas, Dennis G; Gaheen, Sharon; Harper, Stacey L et al. (2013) ISA-TAB-Nano: a specification for sharing nanomaterial research data in spreadsheet-based format. BMC Biotechnol 13:2

Showing the most recent 10 out of 38 publications