The Controlled Exposure Facility (CEF) Core provides expertise and facilities to conduct human and animal exposure studies. The Core is comprised of two technology units overseeing exposure chambers that individually provide controlled atmospheres to human subjects or small animals. The controlled environmental chambers share components of the pollutant generation systems, allowing for development of exposure conditions that recapitulate those encountered in both environmental and occupational settings. The goal of the human exposure unit is to provide accurate exposures of human subjects in a setting where many host and environmental factors can be rigorously controlled and where biological specimens can be collected for discovery of biological response indicators and mechanistic studies. The animal exposure unit provides consultation for conducting animal inhalation research in controlled exposure conditions recapitulating those in the human exposure chamber. The ability to generate different atmospheres with known pollutant concentrations in a controlled environment allows testing and calibration of devices that will be used for field and epidemiological studies.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Center Core Grants (P30)
Project #
Application #
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Medicine & Dentistry of NJ
United States
Zip Code
Tiethof, Angela K; Richardson, Jason R; Hart, Ronald P (2018) Knockdown of Butyrylcholinesterase but Not Inhibition by Chlorpyrifos Alters Early Differentiation Mechanisms in Human Neural Stem Cells. Toxics 6:
Liu, Anna B; Tao, Siyao; Lee, Mao-Jung et al. (2018) Effects of gut microbiota and time of treatment on tissue levels of green tea polyphenols in mice. Biofactors :
Rockafellow-Baldoni, Megan; Spayd, Steven E; Hong, Jun-Yan et al. (2018) Arsenic Exposure and Cancer Risk Reduction with Local Ordinance Requiring Whole-House Dual-Tank Water Treatment Systems. Hum Ecol Risk Assess 24:1256-1267
Jabbar, Shaima; Reuhl, Kenneth; Sarkar, Dipak K (2018) Prenatal alcohol exposure increases the susceptibility to develop aggressive prolactinomas in the pituitary gland. Sci Rep 8:7720
Radbel, Jared; Le-Hoang, Oanh; Vayas, Kinal N et al. (2018) Effect of World Trade Center Dust Exposure and Chronic Intermittent Hypoxia on Macrophage Matrix Metalloproteinase-12 Expression in Mice. Ann Am Thorac Soc 15:S125-S126
Walley, Sabrina N; Roepke, Troy A (2018) Perinatal exposure to endocrine disrupting compounds and the control of feeding behavior-An overview. Horm Behav 101:22-28
Szilagyi, John T; Fussell, Karma C; Wang, Yun et al. (2018) Quinone and nitrofurantoin redox cycling by recombinant cytochrome b5 reductase. Toxicol Appl Pharmacol 359:102-107
Li, Wenji; Yang, Hilly; Buckley, Brian et al. (2018) A Novel Triple Stage Ion Trap MS method validated for curcumin pharmacokinetics application: A comparison summary of the latest validated curcumin LC/MS methods. J Pharm Biomed Anal 156:116-124
Cory-Slechta, D A; Allen, J L; Conrad, K et al. (2018) Developmental exposure to low level ambient ultrafine particle air pollution and cognitive dysfunction. Neurotoxicology 69:217-231
Joseph, Laurie B; Composto, Gabriella M; Perez, Roberto M et al. (2018) Sulfur mustard induced mast cell degranulation in mouse skin is inhibited by a novel anti-inflammatory and anticholinergic bifunctional prodrug. Toxicol Lett 293:77-81

Showing the most recent 10 out of 819 publications