The Integrative Health Sciences Facility is a newly mandated component of the Environmental Health Sciences Core Center Grants program. It represents the interest of the'NIEHS in promoting and supporting translational and clinical research studies """"""""to better understand the impact of environmental exposures on human disease."""""""" Although a new requirement, this emphasis on human studies has been a long-standing strength of the University of Iowa EHSRC. Dr. Kline was initially brought into the Center by Dr. David Schwartz to lead studies, in human subjects, of the responses to common rural and agricultural environmental exposures;the need for infrastructure to conduct such studies with safety (to both research subjects and investigators), reproducibility, and rigorous scientific approaches led to the development of the Clinical Exposure Facility (construction funded by the University of Iowa and the College of Medicine), with these critical capabilities. Since the Clinical Exposure Facility's development, we have expanded the Facility's focus, supporting radiological imaging, bronchoscopies, and other services needed to translate basic investigations into clinical studies. In short, we have developed an Integrative Health Sciences Facility, as described in the most recent Environmental Health Sciences Core Center Grants RFA. Thus, in this current application, we report on the progress of the (previously named) Clinical Exposure Facility Core, and describe our plans for the (future designation) Integrative Health Sciences Facility.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES005605-19
Application #
7798180
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
2009-04-01
Budget End
2010-03-31
Support Year
19
Fiscal Year
2009
Total Cost
$282,049
Indirect Cost
Name
University of Iowa
Department
Type
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Ebeid, Kareem; Meng, Xiangbing; Thiel, Kristina W et al. (2018) Synthetically lethal nanoparticles for treatment of endometrial cancer. Nat Nanotechnol 13:72-81
Herkert, Nicholas J; Spak, Scott N; Smith, Austen et al. (2018) Calibration and evaluation of PUF-PAS sampling rates across the Global Atmospheric Passive Sampling (GAPS) network. Environ Sci Process Impacts 20:210-219
Fisher, Sarah C; Van Zutphen, Alissa R; Romitti, Paul A et al. (2018) Maternal Hypertension, Antihypertensive Medication Use, and Small for Gestational Age Births in the National Birth Defects Prevention Study, 1997-2011. Matern Child Health J 22:237-246
Dhakal, Kiran; Gadupudi, Gopi S; Lehmler, Hans-Joachim et al. (2018) Sources and toxicities of phenolic polychlorinated biphenyls (OH-PCBs). Environ Sci Pollut Res Int 25:16277-16290
Mendy, Angelico; Salo, Päivi M; Cohn, Richard D et al. (2018) House Dust Endotoxin Association with Chronic Bronchitis and Emphysema. Environ Health Perspect 126:037007
Mendy, Angelico; Wilkerson, Jesse; Salo, P?ivi M et al. (2018) Endotoxin predictors and associated respiratory outcomes differ with climate regions in the U.S. Environ Int 112:218-226
Wu, Dan; Boucher, Richard C; Button, Brian et al. (2018) An integrated mathematical epithelial cell model for airway surface liquid regulation by mechanical forces. J Theor Biol 438:34-45
Gourronc, Francoise A; Robertson, Larry W; Klingelhutz, Aloysius J (2018) A delayed proinflammatory response of human preadipocytes to PCB126 is dependent on the aryl hydrocarbon receptor. Environ Sci Pollut Res Int 25:16481-16492
Liu, Ling; Urch, Bruce; Szyszkowicz, Mieczyslaw et al. (2018) Metals and oxidative potential in urban particulate matter influence systemic inflammatory and neural biomarkers: A controlled exposure study. Environ Int 121:1331-1340
Lehmler, Hans-Joachim; Gadogbe, Manuel; Liu, Buyun et al. (2018) Environmental tin exposure in a nationally representative sample of U.S. adults and children: The National Health and Nutrition Examination Survey 2011-2014. Environ Pollut 240:599-606

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