The Integrative Health Sciences Facility is a newly mandated component of the Environmental Health Sciences Core Center Grants program. It represents the interest of the'NIEHS in promoting and supporting translational and clinical research studies """"""""to better understand the impact of environmental exposures on human disease."""""""" Although a new requirement, this emphasis on human studies has been a long-standing strength of the University of Iowa EHSRC. Dr. Kline was initially brought into the Center by Dr. David Schwartz to lead studies, in human subjects, of the responses to common rural and agricultural environmental exposures;the need for infrastructure to conduct such studies with safety (to both research subjects and investigators), reproducibility, and rigorous scientific approaches led to the development of the Clinical Exposure Facility (construction funded by the University of Iowa and the College of Medicine), with these critical capabilities. Since the Clinical Exposure Facility's development, we have expanded the Facility's focus, supporting radiological imaging, bronchoscopies, and other services needed to translate basic investigations into clinical studies. In short, we have developed an Integrative Health Sciences Facility, as described in the most recent Environmental Health Sciences Core Center Grants RFA. Thus, in this current application, we report on the progress of the (previously named) Clinical Exposure Facility Core, and describe our plans for the (future designation) Integrative Health Sciences Facility.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES005605-19
Application #
7798180
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
2009-04-01
Budget End
2010-03-31
Support Year
19
Fiscal Year
2009
Total Cost
$282,049
Indirect Cost
Name
University of Iowa
Department
Type
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
P?n?íková, Kate?ina; Svržková, Lucie; Strapá?ová, Simona et al. (2018) In vitro profiling of toxic effects of prominent environmental lower-chlorinated PCB congeners linked with endocrine disruption and tumor promotion. Environ Pollut 237:473-486
Andreotti, Gabriella; Koutros, Stella; Hofmann, Jonathan N et al. (2018) Glyphosate Use and Cancer Incidence in the Agricultural Health Study. J Natl Cancer Inst 110:509-516
Martinez, Carlos H; Li, Sara X; Hirzel, Andrew J et al. (2018) Alveolar eosinophilia in current smokers with chronic obstructive pulmonary disease in the SPIROMICS cohort. J Allergy Clin Immunol 141:429-432
Schoenfeld, Joshua D; Sibenaller, Zita A; Mapuskar, Kranti A et al. (2018) Redox active metals and H2O2 mediate the increased efficacy of pharmacological ascorbate in combination with gemcitabine or radiation in pre-clinical sarcoma models. Redox Biol 14:417-422
Brandt, Kristin E; Falls, Kelly C; Schoenfeld, Joshua D et al. (2018) Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells. Redox Biol 14:82-87
P?n?íková, Kate?ina; Brenerová, Petra; Svržková, Lucie et al. (2018) Atropisomers of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) exhibit stereoselective effects on activation of nuclear receptors in vitro. Environ Sci Pollut Res Int 25:16411-16419
Bao, Wei; Dar, Sharon; Zhu, Yeyi et al. (2018) Plasma concentrations of lipids during pregnancy and the risk of gestational diabetes mellitus: A longitudinal study. J Diabetes 10:487-495
Leelakanok, Nattawut; Geary, Sean M; Salem, Aliasger K (2018) Antitumor Efficacy and Toxicity of 5-Fluorouracil-Loaded Poly(Lactide Co-glycolide) Pellets. J Pharm Sci 107:690-697
Bodduluri, Sandeep; Reinhardt, Joseph M; Hoffman, Eric A et al. (2018) Recent Advances in Computed Tomography Imaging in Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc 15:281-289
Meyerholz, David K; Sieren, Jessica C; Beck, Amanda P et al. (2018) Approaches to Evaluate Lung Inflammation in Translational Research. Vet Pathol 55:42-52

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