Goals and Aims Our goal is to establish a new Research Cluster to serve as a hub of intellectual activity to build innovative environmental genomics into the EHSRC research portfolio and to serve as a resource that will facilitate the transfer of knowledge, strategy and techniques to junior investigators beginning new programs and established investigators ready to incorporate genomics into existing EHSRC investigations. We will take advantage of successful efforts already in place on our campus with investigators who have a long standing experience of genomics/genetics as well as the capability to provide leadership and guidance. The primary goal in building an environmental genomics research capability is to take advantage of the developments in both laboratory techniques and analytical advances to provide a setting in which investigators can add genetics/genomics to new or ongoing research programs. The initial publication of human genome sequence in 2000 has been followed by a series of ever more startling developments that provide opportunities for individual and population based studies incorporating genetics on a scale that exceeds even the most positive views of just a few years ago. DMA sequencing capabilities, gene expression analysis, proteomics and genotype analysis are now all affordable on a genome scale to even modest size laboratory groups.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES005605-20
Application #
8055959
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
2010-04-01
Budget End
2011-03-31
Support Year
20
Fiscal Year
2010
Total Cost
$34,556
Indirect Cost
Name
University of Iowa
Department
Type
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
P?n?íková, Kate?ina; Brenerová, Petra; Svržková, Lucie et al. (2018) Atropisomers of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) exhibit stereoselective effects on activation of nuclear receptors in vitro. Environ Sci Pollut Res Int 25:16411-16419
Brandt, Kristin E; Falls, Kelly C; Schoenfeld, Joshua D et al. (2018) Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells. Redox Biol 14:82-87
Leelakanok, Nattawut; Geary, Sean M; Salem, Aliasger K (2018) Antitumor Efficacy and Toxicity of 5-Fluorouracil-Loaded Poly(Lactide Co-glycolide) Pellets. J Pharm Sci 107:690-697
Bao, Wei; Dar, Sharon; Zhu, Yeyi et al. (2018) Plasma concentrations of lipids during pregnancy and the risk of gestational diabetes mellitus: A longitudinal study. J Diabetes 10:487-495
Meyerholz, David K; Sieren, Jessica C; Beck, Amanda P et al. (2018) Approaches to Evaluate Lung Inflammation in Translational Research. Vet Pathol 55:42-52
Bodduluri, Sandeep; Reinhardt, Joseph M; Hoffman, Eric A et al. (2018) Recent Advances in Computed Tomography Imaging in Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc 15:281-289
Haghighi, Babak; D Ellingwood, Nathan; Yin, Youbing et al. (2018) A GPU-based symmetric non-rigid image registration method in human lung. Med Biol Eng Comput 56:355-371
Gergen, Peter J; Mitchell, Herman E; Calatroni, Agustin et al. (2018) Sensitization and Exposure to Pets: The Effect on Asthma Morbidity in the US Population. J Allergy Clin Immunol Pract 6:101-107.e2
Oelsner, Elizabeth C; Smith, Benjamin M; Hoffman, Eric A et al. (2018) Associations between emphysema-like lung on CT and incident airflow limitation: a general population-based cohort study. Thorax 73:486-488
Liu, Buyun; Sun, Yangbo; Lehmler, Hans-Joachim et al. (2018) Association between urinary tin concentration and diabetes in nationally representative sample of US adults. J Diabetes 10:977-983

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