1.1 INTRODUCTION AND VISION STATEMENT Since its inception in 1990, Environmental Health Sciences Research Center (EHSRC) at the University of Iowa (U.I.) has advanced and translated research that addresses environmental health problems across the urban-rural continuum. Our early research was focused on organic dust exposure and lung disease, pesticide exposure and cancer, rural childhood asthma, and community health problems arising from industrialized livestock production. While studies in these arenas continue, we have also encompassed areas of emerging importance such as nanotoxicology, oxidative stress and innate immunity and have applied new innovations in environmental genomics, advanced metabolomics, environmental intervention cohort studies and state-of-the-art biomedical imaging. As future environmental health issues come to light, we will continue to embrace their challenges through vigorous research, outreach and community engagement. For example, in the wake of the Iowa Flood of 2008, we are investigating environmental health challenges posed by a warmer, wetter climate in the Midwest. Data collected in Iowa over the last 114 years show more frost-free days, higher annual rainfalls, and increasing days each year with extreme rainfall. Allergenic plants are flowering sooner, producing more pollen and expanding their northern range. Farmers are adapting to climate change by planting earlier and at higher densities;using more pesticides to control yield loss from new insects, fungi and weeds;and expanding use of subsurface drainage systems that channel pesticides and manure into surface waterways. In this example, a changing climate has direct relevance to rural and agricultural populations as well as far-reaching implications for public health along the urban-rural continuum. The EHSRC is translating innovative research on climate change health effects to policy makers and the public to support sound adaptation strategies and to improve our preparedness for environmental disasters with a focus on disease prevention. EHSRC Vision Statement: The Center vision is to be the primary environmental health resource for improving the health of rural residents by stimulating and translating innovative environmental health sciences research. This will be accomplished by gaining new insights into rural exposures;pathways of host defense, lung injury and repair;nanotoxicology;and population health;and then translating these insights to clinical medicine, public health practice and regulatory policy.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Center Core Grants (P30)
Project #
Application #
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Iowa
Iowa City
United States
Zip Code
P?n?íková, Kate?ina; Brenerová, Petra; Svržková, Lucie et al. (2018) Atropisomers of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) exhibit stereoselective effects on activation of nuclear receptors in vitro. Environ Sci Pollut Res Int 25:16411-16419
Brandt, Kristin E; Falls, Kelly C; Schoenfeld, Joshua D et al. (2018) Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells. Redox Biol 14:82-87
Leelakanok, Nattawut; Geary, Sean M; Salem, Aliasger K (2018) Antitumor Efficacy and Toxicity of 5-Fluorouracil-Loaded Poly(Lactide Co-glycolide) Pellets. J Pharm Sci 107:690-697
Bao, Wei; Dar, Sharon; Zhu, Yeyi et al. (2018) Plasma concentrations of lipids during pregnancy and the risk of gestational diabetes mellitus: A longitudinal study. J Diabetes 10:487-495
Meyerholz, David K; Sieren, Jessica C; Beck, Amanda P et al. (2018) Approaches to Evaluate Lung Inflammation in Translational Research. Vet Pathol 55:42-52
Bodduluri, Sandeep; Reinhardt, Joseph M; Hoffman, Eric A et al. (2018) Recent Advances in Computed Tomography Imaging in Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc 15:281-289
Haghighi, Babak; D Ellingwood, Nathan; Yin, Youbing et al. (2018) A GPU-based symmetric non-rigid image registration method in human lung. Med Biol Eng Comput 56:355-371
Gergen, Peter J; Mitchell, Herman E; Calatroni, Agustin et al. (2018) Sensitization and Exposure to Pets: The Effect on Asthma Morbidity in the US Population. J Allergy Clin Immunol Pract 6:101-107.e2
Oelsner, Elizabeth C; Smith, Benjamin M; Hoffman, Eric A et al. (2018) Associations between emphysema-like lung on CT and incident airflow limitation: a general population-based cohort study. Thorax 73:486-488
Liu, Buyun; Sun, Yangbo; Lehmler, Hans-Joachim et al. (2018) Association between urinary tin concentration and diabetes in nationally representative sample of US adults. J Diabetes 10:977-983

Showing the most recent 10 out of 1123 publications