- OVERALL Building on a 26-year history, the Environmental Health Sciences Research Center (EHSRC) will advance and translate cutting edge research that addresses environmental health problems across the urban-rural continuum. Rural America faces unique environmental challenges from exposures to farm chemicals, air and water pollution from livestock and agricultural production, rural manufacturing, and the green energy economy. The EHSRC is at the forefront of research in rural environmental health, determining the role of the microbiome in environmental lung disease; elucidating novel pathways of oxidative stress and innate immunity; investigating epigenetic mechanisms of cell alterations; discovering therapeutic modalities to treat environmental disease; and characterizing adverse outcome pathways of engineered nanomaterials, pesticides and other xenobiotics. The EHSRC vision is to be the primary environmental health sciences (EHS) resource for improving the health of rural residents by stimulating and translating innovative EHS research. This is accomplished by gaining new insights into rural exposures; population health; susceptibilities; and pathways of toxicity and repair; and then translating these insights to medicine, public health practice and regulatory policy. Center goals are to: 1) Develop, support and expand innovative interdisciplinary EHS research in key Thematic Areas; 2) Recruit, mentor and nurture talented new and mid-level investigators in EHS; and 3) Engage with communities and policy makers to translate research findings toward improving the health and environment of rural people in the Midwest and the nation. The interdisciplinary research of the EHSRC is organized around Thematic Areas which are: Inflammation and Innate Immunity, Oxidative Stress and Metabolism, Nanotoxicology, and Environmental Disease and Population Health. Three EHSRC facility cores: Integrative Health Sciences Facility, Pulmonary Toxicology Facility, and Environmental Modeling & Exposure Assessment Facility, provide cutting edge services, state-of-the-art equipment and support the authentication of key biological and chemical resources. An Administrative Core provides transformative leadership, leverages institutional support and manages highly effective Pilot Grant and Career Development Programs that provide resources and mentoring to advance the careers of promising and diverse young investigators. The Community Outreach and Engagement Core engages stakeholders in multidirectional communications to ensure relevance of EHSRC research and to translate research findings to environmental public health. Lastly, the EHSRC responds to environmental disasters disseminating accurate and timely information and collecting real-time data on the severity of the disaster and effectiveness of the response.

Public Health Relevance

- OVERALL The Environmental Health Sciences Research Center (EHSRC) is the primary environmental health sciences resource for improving the health of rural residents by stimulating and translating innovative research. This is accomplished by supporting original research addressing rural exposures; population health; susceptibilities; and pathways of toxicity and repair; and then translating this knowledge to medicine, public health practice and regulatory policy. The EHSRC supports four thematic areas which serve as intellectual hubs, three research facility cores, a Pilot Grant Program, a Career Development Program and a Community Outreach and Engagement Core.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES005605-28
Application #
9478765
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Thompson, Claudia L
Project Start
1997-04-01
Project End
2022-03-31
Budget Start
2018-04-01
Budget End
2019-03-31
Support Year
28
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Iowa
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Liu, Ling; Urch, Bruce; Szyszkowicz, Mieczyslaw et al. (2018) Metals and oxidative potential in urban particulate matter influence systemic inflammatory and neural biomarkers: A controlled exposure study. Environ Int 121:1331-1340
Lehmler, Hans-Joachim; Gadogbe, Manuel; Liu, Buyun et al. (2018) Environmental tin exposure in a nationally representative sample of U.S. adults and children: The National Health and Nutrition Examination Survey 2011-2014. Environ Pollut 240:599-606
Gilbert, Paul A; Laroche, Helena H; Wallace, Robert B et al. (2018) Extending Work on Rural Health Disparities: A Commentary on Matthews and Colleagues' Report. J Rural Health 34:119-121
Li, Xueshu; Holland, Erika B; Feng, Wei et al. (2018) Authentication of synthetic environmental contaminants and their (bio)transformation products in toxicology: polychlorinated biphenyls as an example. Environ Sci Pollut Res Int 25:16508-16521
Stapleton, Emma M; O'Shaughnessy, Patrick T; Locke, Sarah J et al. (2018) A task-based analysis of black carbon exposure in Iowa farmers during harvest. J Occup Environ Hyg 15:293-304
Andreotti, Gabriella; Koutros, Stella; Hofmann, Jonathan N et al. (2018) Glyphosate Use and Cancer Incidence in the Agricultural Health Study. J Natl Cancer Inst 110:509-516
P?n?íková, Kate?ina; Svržková, Lucie; Strapá?ová, Simona et al. (2018) In vitro profiling of toxic effects of prominent environmental lower-chlorinated PCB congeners linked with endocrine disruption and tumor promotion. Environ Pollut 237:473-486
Schoenfeld, Joshua D; Sibenaller, Zita A; Mapuskar, Kranti A et al. (2018) Redox active metals and H2O2 mediate the increased efficacy of pharmacological ascorbate in combination with gemcitabine or radiation in pre-clinical sarcoma models. Redox Biol 14:417-422
Martinez, Carlos H; Li, Sara X; Hirzel, Andrew J et al. (2018) Alveolar eosinophilia in current smokers with chronic obstructive pulmonary disease in the SPIROMICS cohort. J Allergy Clin Immunol 141:429-432
Brandt, Kristin E; Falls, Kelly C; Schoenfeld, Joshua D et al. (2018) Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells. Redox Biol 14:82-87

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