Benign and harmful algal blooms (HABS) have likely been occurring since the very beginnings of life on this planet. However, it appears that the incidence of harmful algal blooms has been on the rise in recent years. For the applicant's purposes, an algal bloom is harmful if its toxins become available to human populations, either directly or indirectly, through food, water and other routes of exposure. As indicated in the application, toxins may adversely affect both aquatic animals and humans, and thus it is advisable to follow both human and wildlife effects, because wildlife can ultimately become food sources for humans, but they can also serve as early warning sentinels of new toxins or new HABs. The traditional primary exposure route of concern to humans has been bio-accumulation in finfish (e.g., ciguatoxin) or shellfish (e.g., saxitoxin and brevetoxin). University of Miami Center scientists have been at the forefront of dealing with the human health aspects of these phenomena. However, anecdotal evidence has been accumulating about the toxic effects of other exposure routes (e g., aerosols and even drinking water), and in the next grant period, Center scientists will be conducting a definitive evaluation of such effects in both animal and human models. Awareness of these new routes of exposure came about as a consequence not only of our wildlife work on manatees, but also as a result of reports on out Marine and Freshwater Hotline and through work with the Florida Harmful Algal Bloom Taskforce, i.e., via our outreach activities.
| Gojova, Andrea; Lee, Jun-Tae; Jung, Heejung S et al. (2009) Effect of cerium oxide nanoparticles on inflammation in vascular endothelial cells. Inhal Toxicol 21 Suppl 1:123-30 |
| Walsh, Patrick J; Veauvy, Clemence M; McDonald, M Danielle et al. (2007) Piscine insights into comparisons of anoxia tolerance, ammonia toxicity, stroke and hepatic encephalopathy. Comp Biochem Physiol A Mol Integr Physiol 147:332-43 |
| An, Tianying; Kumar, Thallapuranam Krishnaswamy Suresh; Wang, Minglei et al. (2007) Structures of pahayokolides A and B, cyclic peptides from a Lyngbya sp. J Nat Prod 70:730-5 |
| Gojova, Andrea; Guo, Bing; Kota, Rama S et al. (2007) Induction of inflammation in vascular endothelial cells by metal oxide nanoparticles: effect of particle composition. Environ Health Perspect 115:403-9 |
| Hudder, Alice; Song, Weihua; O'Shea, Kevin E et al. (2007) Toxicogenomic evaluation of microcystin-LR treated with ultrasonic irradiation. Toxicol Appl Pharmacol 220:357-64 |
| Shibata, Tomoyuki; Solo-Gabriele, Helena M; Fleming, Lora E et al. (2007) A mass balance approach for evaluating leachable arsenic and chromium from an in-service CCA-treated wood structure. Sci Total Environ 372:624-35 |
| Begier, Elizabeth M; Backer, Lorraine C; Weisman, Richard S et al. (2006) Outbreak bias in illness reporting and case confirmation in ciguatera fish poisoning surveillance in south Florida. Public Health Rep 121:658-65 |
| Nishi, Kosuke; Huang, Huazhang; Kamita, Shizuo G et al. (2006) Characterization of pyrethroid hydrolysis by the human liver carboxylesterases hCE-1 and hCE-2. Arch Biochem Biophys 445:115-23 |
| Shalat, S L; Solo-Gabriele, H M; Fleming, L E et al. (2006) A pilot study of children's exposure to CCA-treated wood from playground equipment. Sci Total Environ 367:80-8 |
| Dey, Aparajita; Williams, Roger S; Pollock, David M et al. (2004) Altered kidney CYP2C and cyclooxygenase-2 levels are associated with obesity-related albuminuria. Obes Res 12:1278-89 |
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