Abstract

This Core will focus on the role of genetic susceptibility in toxic responses to environmental agents. Its stated long-range goal is, """"""""to identify and characterize genetic polymorphisms concerning differences in response to environmental agents - responses include tumorigenesis as well as acute and chronic toxicity."""""""" There are six specific aims stated for this Research Core: 1) to elucidate mechanisms of gene expression and regulation through genetic variants; 2) to screen populations and three- generation families for differences in toxic responses; 3) to determine associations between a genetic locus and a phenotypic trait; 4) to understand the molecular basis of a polymorphism; 5) to study the interaction of genes and agents during embryogenesis; and 6) to evaluate the impact of each polymorphism on human health.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
2P30ES006096-06A1
Application #
6239648
Study Section
Project Start
1997-09-30
Project End
1998-03-31
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
6
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
University of Cincinnati
Department
Type
DUNS #
City
Cincinnati
State
OH
Country
United States
Zip Code
45221

  Publications

Bermúdez, Mei-Ling; Skelton, Matthew R; Genter, Mary Beth (2018) Intranasal carnosine attenuates transcriptomic alterations and improves mitochondrial function in the Thy1-aSyn mouse model of Parkinson's disease. Mol Genet Metab 125:305-313
Reigle, Beverly S; Zhang, Bin (2018) Women's Rehabilitation Experiences Following Breast Cancer Surgery. Rehabil Nurs 43:195-200
Whitt, Jordan; Woo, Vivienne; Lee, Patrick et al. (2018) Disruption of Epithelial HDAC3 in Intestine Prevents Diet-Induced Obesity in Mice. Gastroenterology 155:501-513
Uno, Shigeyuki; Nebert, Daniel W; Makishima, Makoto (2018) Cytochrome P450 1A1 (CYP1A1) protects against nonalcoholic fatty liver disease caused by Western diet containing benzo[a]pyrene in mice. Food Chem Toxicol 113:73-82
Vuong, Ann M; Yolton, Kimberly; Poston, Kendra L et al. (2018) Childhood polybrominated diphenyl ether (PBDE) exposure and executive function in children in the HOME Study. Int J Hyg Environ Health 221:87-94
Lee, Alison G; Le Grand, Blake; Hsu, Hsiao-Hsien Leon et al. (2018) Prenatal fine particulate exposure associated with reduced childhood lung function and nasal epithelia GSTP1 hypermethylation: Sex-specific effects. Respir Res 19:76
Leung, Yuet-Kin; Ouyang, Bin; Niu, Liang et al. (2018) Identification of sex-specific DNA methylation changes driven by specific chemicals in cord blood in a Faroese birth cohort. Epigenetics 13:290-300
Kim, Stephani; Xu, Xijin; Zhang, Yuling et al. (2018) Metal concentrations in pregnant women and neonates from informal electronic waste recycling. J Expo Sci Environ Epidemiol :
Chen, Jing; Gálvez-Peralta, Marina; Zhang, Xiang et al. (2018) In utero gene expression in the Slc39a8(neo/neo) knockdown mouse. Sci Rep 8:10703
Abdel-Hameed, Enass A; Rouster, Susan D; Boyce, Ceejay L et al. (2018) Ultra-Deep Genomic Sequencing of HCV NS5A Resistance-Associated Substitutions in HCV/HIV Coinfected Patients. Dig Dis Sci 63:645-652

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