Abstract

This Core will focus on the role of genetic susceptibility in toxic responses to environmental agents. Its stated long-range goal is, """"""""to identify and characterize genetic polymorphisms concerning differences in response to environmental agents - responses include tumorigenesis as well as acute and chronic toxicity."""""""" There are six specific aims stated for this Research Core: 1) to elucidate mechanisms of gene expression and regulation through genetic variants; 2) to screen populations and three- generation families for differences in toxic responses; 3) to determine associations between a genetic locus and a phenotypic trait; 4) to understand the molecular basis of a polymorphism; 5) to study the interaction of genes and agents during embryogenesis; and 6) to evaluate the impact of each polymorphism on human health.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES006096-08
Application #
6106358
Study Section
Project Start
1999-04-01
Project End
2000-03-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
8
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Cincinnati
Department
Type
DUNS #
City
Cincinnati
State
OH
Country
United States
Zip Code
45221

  Publications

Lee, Alison G; Le Grand, Blake; Hsu, Hsiao-Hsien Leon et al. (2018) Prenatal fine particulate exposure associated with reduced childhood lung function and nasal epithelia GSTP1 hypermethylation: Sex-specific effects. Respir Res 19:76
Leung, Yuet-Kin; Ouyang, Bin; Niu, Liang et al. (2018) Identification of sex-specific DNA methylation changes driven by specific chemicals in cord blood in a Faroese birth cohort. Epigenetics 13:290-300
Kim, Stephani; Xu, Xijin; Zhang, Yuling et al. (2018) Metal concentrations in pregnant women and neonates from informal electronic waste recycling. J Expo Sci Environ Epidemiol :
Chen, Jing; Gálvez-Peralta, Marina; Zhang, Xiang et al. (2018) In utero gene expression in the Slc39a8(neo/neo) knockdown mouse. Sci Rep 8:10703
Abdel-Hameed, Enass A; Rouster, Susan D; Boyce, Ceejay L et al. (2018) Ultra-Deep Genomic Sequencing of HCV NS5A Resistance-Associated Substitutions in HCV/HIV Coinfected Patients. Dig Dis Sci 63:645-652
Dobraca, Dina; Lum, Raymond; Sjödin, Andreas et al. (2018) Urinary biomarkers of polycyclic aromatic hydrocarbons in pre- and peri-pubertal girls in Northern California: Predictors of exposure and temporal variability. Environ Res 165:46-54
Miller, Marian L; Porollo, Aleksey; Wert, Susan (2018) Ultrastructure of Highly Ordered Granules in Alveolar Type II Cells in Several Species. Anat Rec (Hoboken) :
Ren, Sheng; Haynes, Erin; Hall, Eric et al. (2018) Periconception Exposure to Air Pollution and Risk of Congenital Malformations. J Pediatr 193:76-84.e6
Bhattacharya, Sukanta S; Yadav, Jagjit S (2018) Microbial P450 Enzymes in Bioremediation and Drug Discovery: Emerging Potentials and Challenges. Curr Protein Pept Sci 19:75-86
VonHandorf, Andrew; Sánchez-Martín, Francisco Javier; Biesiada, Jacek et al. (2018) Chromium disrupts chromatin organization and CTCF access to its cognate sites in promoters of differentially expressed genes. Epigenetics 13:363-375

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