Abstract

The overall goal of this Core is to investigate the genetic determinants and molecular mechanisms controlling pulmonary diseases induced or exacerbated by environmental agents. Research areas include the genetic basis of increased susceptibility to ozone or oxidant injury, the effects of ozone on surfactants proteins A and B, receptor G-protein coupling and other genetic determinants of asthma, gene transcription regulated by changes in oxygen concentration, and use of transgenic mouse models to study the molecular biology of pulmonary disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES006096-09
Application #
6367991
Study Section
Project Start
2000-04-01
Project End
2001-03-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
9
Fiscal Year
2000
Total Cost
$156,647
Indirect Cost

  Institution

Name
University of Cincinnati
Department
Type
DUNS #
City
Cincinnati
State
OH
Country
United States
Zip Code
45221

  Publications

Kim, Dasom; Chen, Zi; Zhou, Lin-Fu et al. (2018) Air pollutants and early origins of respiratory diseases. Chronic Dis Transl Med 4:75-94
Brunst, Kelly J; Sanchez-Guerra, Marco; Chiu, Yueh-Hsiu Mathilda et al. (2018) Prenatal particulate matter exposure and mitochondrial dysfunction at the maternal-fetal interface: Effect modification by maternal lifetime trauma and child sex. Environ Int 112:49-58
Isiugo, Kelechi; Newman, Nicholas; Jandarov, Roman et al. (2018) Assessing the accuracy of commercially available gas sensors for the measurement of ambient ozone and nitrogen dioxide. J Occup Environ Hyg 15:782-791
Li, Tao; Hu, Rong; Chen, Zi et al. (2018) Fine particulate matter (PM2.5): The culprit for chronic lung diseases in China. Chronic Dis Transl Med 4:176-186
Zhang, Xue; Biagini Myers, Jocelyn M; Burleson, J D et al. (2018) Nasal DNA methylation is associated with childhood asthma. Epigenomics 10:629-641
Haynes, Erin N; Sucharew, Heidi; Hilbert, Timothy J et al. (2018) Impact of air manganese on child neurodevelopment in East Liverpool, Ohio. Neurotoxicology 64:94-102
Bermúdez, Mei-Ling; Skelton, Matthew R; Genter, Mary Beth (2018) Intranasal carnosine attenuates transcriptomic alterations and improves mitochondrial function in the Thy1-aSyn mouse model of Parkinson's disease. Mol Genet Metab 125:305-313
Reigle, Beverly S; Zhang, Bin (2018) Women's Rehabilitation Experiences Following Breast Cancer Surgery. Rehabil Nurs 43:195-200
Whitt, Jordan; Woo, Vivienne; Lee, Patrick et al. (2018) Disruption of Epithelial HDAC3 in Intestine Prevents Diet-Induced Obesity in Mice. Gastroenterology 155:501-513
Uno, Shigeyuki; Nebert, Daniel W; Makishima, Makoto (2018) Cytochrome P450 1A1 (CYP1A1) protects against nonalcoholic fatty liver disease caused by Western diet containing benzo[a]pyrene in mice. Food Chem Toxicol 113:73-82

Showing the most recent 10 out of 979 publications