The mission of the Cell Culture Facility Core (CCFC) is to support the goals of the EHS Center Research Cores by providing their investigators with the cell culture systems, methodologies, equipment and technical assistance that will enable them to address important questions in the environmental health sciences, with human emphasis. The CCFC mission is accomplished by providing 1) physical space, equipment and supplies for performing cell culture work, 2) cell culture services that meet the needs of the Center Research Core members and 3) technical assistance, education and training. By providing Center investigators with these services and capabilities, the CCFC represents an enabling resource that facilitates the design and implementation of new collaborative, multi-disciplinary research projects. The CCFC was one of the four original facility cores that were established with the EHS Center. The CCFC currently occupies laboratories measuring more than 1,000 square feet that are outfitted with all equipment necessary to perform routine cell culture work, as well as specialized cell culture activities. Eleven services are offered through the CCFC, the primary goals of which are to 1) help investigators place cells into culture, 2) help investigators perform their own cell culture experiments, 3) improve the consistency and quality of cell cultures and 4) enhance the abilities of investigators to study biological processes in mechanistic detail. During the past funding cycle, the CCFC has supported the research activities of 22 Center members, and has enhanced the productivity of these investigators. In addition, the CCFC has catalyzed the emergence of new research ideas via continuous collaborations among Center investigators.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES006639-13
Application #
7550915
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
2006-04-01
Budget End
2007-03-31
Support Year
13
Fiscal Year
2006
Total Cost
$222,178
Indirect Cost
Name
Wayne State University
Department
Type
DUNS #
001962224
City
Detroit
State
MI
Country
United States
Zip Code
48202
Nakajima, Kosei; Kho, Dhong Hyo; Yanagawa, Takashi et al. (2016) Galectin-3 Cleavage Alters Bone Remodeling: Different Outcomes in Breast and Prostate Cancer Skeletal Metastasis. Cancer Res 76:1391-402
Dombkowski, Alan A; Batista, Carlos E; Cukovic, Daniela et al. (2016) Cortical Tubers: Windows into Dysregulation of Epilepsy Risk and Synaptic Signaling Genes by MicroRNAs. Cereb Cortex 26:1059-71
Sanders, Matthew A; Madoux, Franck; Mladenovic, Ljiljana et al. (2015) Endogenous and Synthetic ABHD5 Ligands Regulate ABHD5-Perilipin Interactions and Lipolysis in Fat and Muscle. Cell Metab 22:851-60
Zhang, Yi; Chopp, Michael; Liu, Xian Shuang et al. (2015) MicroRNAs in the axon locally mediate the effects of chondroitin sulfate proteoglycans and cGMP on axonal growth. Dev Neurobiol 75:1402-19
Kim, Haejin; Johnson, Christine C (2014) The association between acetaminophen and asthma: is there anything to learn from the upper airways? Curr Opin Allergy Clin Immunol 14:25-8
Wu, Hongli; Yu, Yibo; David, Larry et al. (2014) Glutaredoxin 2 (Grx2) gene deletion induces early onset of age-dependent cataracts in mice. J Biol Chem 289:36125-39
D'Angelo, Rosemarie Chirco; Liu, Xu-Wen; Najy, Abdo J et al. (2014) TIMP-1 via TWIST1 induces EMT phenotypes in human breast epithelial cells. Mol Cancer Res 12:1324-33
Deranieh, Rania M; He, Quan; Caruso, Joseph A et al. (2013) Phosphorylation regulates myo-inositol-3-phosphate synthase: a novel regulatory mechanism of inositol biosynthesis. J Biol Chem 288:26822-33
Dzinic, Sijana H; Kaplun, Alexander; Li, Xiaohua et al. (2013) Identification of an intrinsic determinant critical for maspin subcellular localization and function. PLoS One 8:e74502
Moin, Kamiar; Sameni, Mansoureh; Victor, Bernadette C et al. (2012) 3D/4D functional imaging of tumor-associated proteolysis: impact of microenvironment. Methods Enzymol 506:175-94

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