Abstract

The Molecular Genetics Core provides NIEHS Center investigators a variety of services and technical support in the areas of recombinant DNA technology, gene expression analysis and molecular genetics. While recombinant DNA technology remains an essential part of many of the research projects in the Center, there is an increasing demand for more sophisticated support for site-directed mutagenesis, bacterial and eukaryotic expression constructs, and construction of plasmids to create transgenic and knockout mice by Center investigators. In addition, the Molecular Genetics Core has developed facilities for expression analysis using both Affymetrix GeneChips as well as custom microarray technologies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
2P30ES006676-11
Application #
6872711
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
2005-04-01
Project End
2010-03-31
Budget Start
2005-04-01
Budget End
2006-03-31
Support Year
11
Fiscal Year
2005
Total Cost
$396,873
Indirect Cost

  Institution

Name
University of Texas Medical Br Galveston
Department
Type
DUNS #
800771149
City
Galveston
State
TX
Country
United States
Zip Code
77555

  Publications

Bao, Xiaoyong; Kolli, Deepthi; Esham, Dana et al. (2018) Human Metapneumovirus Small Hydrophobic Protein Inhibits Interferon Induction in Plasmacytoid Dendritic Cells. Viruses 10:
Amer, Samir M; Bhopale, Kamlesh K; Kakumanu, Ramu D et al. (2018) Hepatic alcohol dehydrogenase deficiency induces pancreatic injury in chronic ethanol feeding model of deer mice. Exp Mol Pathol 104:89-97
Chahar, Harendra Singh; Corsello, Tiziana; Kudlicki, Andrzej S et al. (2018) Respiratory Syncytial Virus Infection Changes Cargo Composition of Exosome Released from Airway Epithelial Cells. Sci Rep 8:387
Speidel, Jordan T; Xu, Meixiang; Abdel-Rahman, Sherif Z (2018) Differential effect of ABCB1 haplotypes on promoter activity. Pharmacogenet Genomics 28:69-77
Graber, Ted G; Rawls, Brandy L; Tian, Bing et al. (2018) Repetitive TLR3 activation in the lung induces skeletal muscle adaptations and cachexia. Exp Gerontol 106:88-100
Yoon, Jung-Hoon; Hodge, Richard P; Hackfeld, Linda C et al. (2018) Genetic control of predominantly error-free replication through an acrolein-derived minor-groove DNA adduct. J Biol Chem 293:2949-2958
Prochaska, John D; Buschmann, Robert N; Jupiter, Daniel et al. (2018) Subjective neighborhood assessment and physical inactivity: An examination of neighborhood-level variance. Prev Med 111:336-341
Tian, Bing; Yang, Jun; Zhao, Yingxin et al. (2018) Central Role of the NF-?B Pathway in the Scgb1a1-Expressing Epithelium in Mediating Respiratory Syncytial Virus-Induced Airway Inflammation. J Virol 92:
Speidel, Jordan T; Xu, Meixiang; Abdel-Rahman, Sherif Z (2018) Bisphenol A (BPA) and bisphenol S (BPS) alter the promoter activity of the ABCB1 gene encoding P-glycoprotein in the human placenta in a haplotype-dependent manner. Toxicol Appl Pharmacol 359:47-54
Speidel, Jordan T; Xu, Meixiang; Abdel-Rahman, Sherif Z (2018) Promoter Haplotypes of the ABCB1 Gene Encoding the P-Glycoprotein Differentially Affect Its Promoter Activity by Altering Transcription Factor Binding. DNA Cell Biol 37:973-981

Showing the most recent 10 out of 601 publications