Through the NIEHS Center Core Grant Program the University of Arizona Center for Toxicology will develop the Southwest Environmental Health Sciences Center (SWEHSC), at the University of Arizona. The EHSC will be a major component of the University of Arizona Center for Toxicology, which was established by the Arizona Board of Regents in 1987. The mission of the EHSC is to integrate, coordinate and expand interactions among a group of established investigators conducting high quality research in the area of environmental health sciences. This mission will be fulfilled by fostering interdisciplinary approaches to understanding mechanisms by which environmental chemicals impact human health and to identifying factors that affect these mechanisms. Thirty-two SWEHSC Investigators have formed four interdisciplinary Research Programs that represent current research activities and provide the basis for new research initiatives. These Programs are Biotransformation, Metals, Cell Injury and Environmental Genetics. To increase productivity and enhance the quality of research being conducted in each of these Research Programs, three Service Cores (Synthetic Chemistry, Analytical Services, Experimental Pathology) have been formed. These cores will offer certain routine services and assist investigators in introducing new methodologies into their research. In addition to the three Service Cores, a Transgenic Animal Facility will be developed within the Environmental Genetics Research Program. The Administrative Core will provide enrichment programs for SWEHSC investigators through seminars and workshops, recruit new SWEHSC Investigators both from within and outside the University of Arizona, promote opportunities for innovative research ideas through the Pilot Projects Program, and oversee all activities. The Community Outreach and Education Program will encourage students, particularly minority students to consider careers in environmental health; establish collaborative research and education programs in Mexico; and offer programs in environmental sciences to health related professionals. The SWEHSC will be a regional representative of NIEHS serving citizens in the Southwest. Because of the proximity of this area to Mexico and collaborative interactions to develop environmental health science programs in that country, SWEHSC will have a positive health impact on citizens on both sides of the border.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
3P30ES006694-08S1
Application #
6493194
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Dearry, Allen
Project Start
1994-04-01
Project End
2004-03-31
Budget Start
2001-04-01
Budget End
2002-03-31
Support Year
8
Fiscal Year
2001
Total Cost
$100,000
Indirect Cost
Name
University of Arizona
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Dodson, Matthew; Liu, Pengfei; Jiang, Tao et al. (2018) Increased O-GlcNAcylation of SNAP29 drives arsenic-induced autophagic dysfunction. Mol Cell Biol :
Griggs, Chanel A; Malm, Scott W; Jaime-Frias, Rosa et al. (2018) Valproic acid disrupts the oscillatory expression of core circadian rhythm transcription factors. Toxicol Appl Pharmacol 339:110-120
Toth, Erica L; Li, Hui; Dzierlenga, Anika L et al. (2018) Gene-by-Environment Interaction of Bcrp-/- and Methionine- and Choline-Deficient Diet-Induced Nonalcoholic Steatohepatitis Alters SN-38 Disposition. Drug Metab Dispos 46:1478-1486
Malm, S W; Amouzougan, E A; Klimecki, W T (2018) Fetal bovine serum induces sustained, but reversible, epithelial-mesenchymal transition in the BEAS-2B cell line. Toxicol In Vitro 50:383-390
Rojo de la Vega, Montserrat; Zhang, Donna D; Wondrak, Georg T (2018) Topical Bixin Confers NRF2-Dependent Protection Against Photodamage and Hair Graying in Mouse Skin. Front Pharmacol 9:287
Harris, Alondra P; Ismail, Kareem A; Nunez, Martha et al. (2018) Trichloroethylene perturbs HNF4a expression and activity in the developing chick heart. Toxicol Lett 285:113-120
Dzierlenga, Anika L; Cherrington, Nathan J (2018) Misregulation of membrane trafficking processes in human nonalcoholic steatohepatitis. J Biochem Mol Toxicol 32:e22035
Yellowhair, Monica; Romanotto, Michelle R; Stearns, Diane M et al. (2018) Uranyl acetate induced DNA single strand breaks and AP sites in Chinese hamster ovary cells. Toxicol Appl Pharmacol 349:29-38
Wales, Jessica A; Chen, Cheng-Yu; Breci, Linda et al. (2018) Discovery of stimulator binding to a conserved pocket in the heme domain of soluble guanylyl cyclase. J Biol Chem 293:1850-1864
Polley, D J; Mihara, K; Ramachandran, R et al. (2017) Cockroach allergen serine proteinases: Isolation, sequencing and signalling via proteinase-activated receptor-2. Clin Exp Allergy 47:946-960

Showing the most recent 10 out of 942 publications