The theme of the Center for Ecogenetics and Environmental Health (CEEH) is """"""""Biochemical and Molecular Mechanisms Underlying Human Variability in Response to Environmental Exposures"""""""". The interactions between genetics and environmental are complex, and defy explanation through traditional through traditional disciplinary pathways of investigation. The purpose of the CEEH is to provide an administrative infrastructure and technical support to foster the disciplinary collaborations necessary to extend basic mechanistic studies of environmental health problems to direct application in human populations. The center consists of 5 research cores: 1) Biotransformation and Disposition, 2) Carcinogenesis, 3) Reproductive and Developmental Toxicology, 4) Neurotoxicology, and 5) Cardiopulmonary Susceptibility. Each of these Cores consists of 7-10 senior investigators and 2-5 associate investigators representing several different departments and programs throughout the University. The funded research of these investigators is enhanced by 5 facility cores which provide access to: 1) electron spin resonance spectroscopy, 2) state-of-the-art molecular biology tools and resources to assist in the conduct of large scale molecular biomarker work, 3) analytical cytology techniques such as flow cytometry and fluorescence activated quantitative cytometry, 4) support for development and maintenance of transgenic animals of value in toxicological research, and 5) molecular structure visualization. The Pilot Projects Program supports 6 exploratory research projects into innovative new ideas related to the theme of the CEEH for one year. A Community Outreach and Education provides a mechanism to disseminate important research findings of CEEH investigators to the general community, as well as a coordinating function to extend and enhance existing community education programs to include more emphasis on issues related to environmental health sciences. An Ethical, Legal & Social Issues (ELSI) core is being proposed which will explore the ethnical, legal and social issues surrounding the area of public health genetics and human genome research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES007033-09
Application #
6635462
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Collman, Gwen W
Project Start
1995-04-01
Project End
2005-03-31
Budget Start
2003-04-01
Budget End
2004-03-31
Support Year
9
Fiscal Year
2003
Total Cost
$1,419,158
Indirect Cost
Name
University of Washington
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Wong, Timothy; Wang, Zhican; Chapron, Brian D et al. (2018) Polymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D3-3-O-Sulfate, a Major Circulating Vitamin D Metabolite in Humans. Drug Metab Dispos 46:367-379
Riley, Erin A; Carpenter, Emily E; Ramsay, Joemy et al. (2018) Evaluation of 1-Nitropyrene as a Surrogate Measure for Diesel Exhaust. Ann Work Expo Health 62:339-350
Cheng, Sunny Lihua; Li, Xueshu; Lehmler, Hans-Joachim et al. (2018) Gut Microbiota Modulates Interactions Between Polychlorinated Biphenyls and Bile Acid Homeostasis. Toxicol Sci 166:269-287
Badon, Sylvia E; Littman, Alyson J; Chan, Kwun Chuen Gary et al. (2018) Physical activity and epigenetic biomarkers in maternal blood during pregnancy. Epigenomics 10:1383-1395
Kim, Young Hun; Jo, Mi Seong; Kim, Jin Kwon et al. (2018) Short-term inhalation study of graphene oxide nanoplates. Nanotoxicology 12:224-238
Woods, Nancy Fugate; Cray, Lori A; Mitchell, Ellen Sullivan et al. (2018) Polymorphisms in Estrogen Synthesis Genes and Symptom Clusters During the Menopausal Transition and Early Postmenopause: Observations From the Seattle Midlife Women's Health Study. Biol Res Nurs 20:153-160
Lee, Ji Hyun; Gulumian, Mary; Faustman, Elaine M et al. (2018) Blood Biochemical and Hematological Study after Subacute Intravenous Injection of Gold and Silver Nanoparticles and Coadministered Gold and Silver Nanoparticles of Similar Sizes. Biomed Res Int 2018:8460910
Weldon, Brittany A; Griffith, William C; Workman, Tomomi et al. (2018) In vitro to in vivo benchmark dose comparisons to inform risk assessment of quantum dot nanomaterials. Wiley Interdiscip Rev Nanomed Nanobiotechnol 10:e1507
Dempsey, Joseph; Zhang, Angela; Cui, Julia Yue (2018) Coordinate regulation of long non-coding RNAs and protein-coding genes in germ-free mice. BMC Genomics 19:834
Rooney, James P K; Woods, Nancy F; Martin, Michael D et al. (2018) Genetic polymorphisms of GRIN2A and GRIN2B modify the neurobehavioral effects of low-level lead exposure in children. Environ Res 165:1-10

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