The theme of this Center is """"""""Biochemical and Molecular Mechanisms Underlying Human Variability in Response to Environmental Exposures"""""""". The interactions between genetics and environment are complex, and defy explanation through traditional disciplinary pathways of investigation. The purpose of this NIEHS Center is to provide an administrative infrastructure and technical support to foster the multidisciplinary collaborations necessary to extend basic mechanistic studies on environmental health problems to direct application in human populations. This center consists of 6 research cores: 1) Gastrointestinal and Renal Toxicology, 2) Carcinogenesis, 3) Reproductive and Developmental Toxicology, 4) Neurotoxicology, 5) Cardiovascular Respiratory Toxicology, and 6) Bioinformatics and Biostatistical Methodologies. Each of these Cores consists of 7 - 10 senior investigators and 2 - 5 associate investigators representing several different departments and programs throughout the University. The funded research of these core faculty is enhanced by 5 Facility cores which provide Center investigators access to: 1) Functional Genomics, 2) Functional Proteomics, 3) Analytical Cytology, techniques such as flow cytometry and fluorescence activated quantitative cytometry, 4) Transgenic Animal Services, support for development and maintenance of transgenic animals of value in toxicological research, and 5) Bioinformatics and Biostatistics, provides guidance for research statistical data. The Pilot Projects support five exploratory research projects into innovative new ideas related to the theme of the Center for one year. A Community Outreach and Education Core provides a mechanism to disseminate important research findings of Center investigators to the general community, as well as a coordinating function to extend and enhance existing community education programs to include more emphasis on issues related to environmental health sciences. The Ethical, Legal and Social Issues (ELSI) Core provides the researchers with the latest information dealing with these issues.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
2P30ES007033-11
Application #
6851852
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Reinlib, Leslie J
Project Start
1997-04-01
Project End
2010-03-31
Budget Start
2005-05-02
Budget End
2006-03-31
Support Year
11
Fiscal Year
2005
Total Cost
$1,506,171
Indirect Cost
Name
University of Washington
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Khan, Burhan A; Robinson, Renee; Fohner, Alison E et al. (2018) Cytochrome P450 Genetic Variation Associated with Tamoxifen Biotransformation in American Indian and Alaska Native People. Clin Transl Sci 11:312-321
Tanner, Julie-Anne; Zhu, Andy Z; Claw, Katrina G et al. (2018) Novel CYP2A6 diplotypes identified through next-generation sequencing are associated with in-vitro and in-vivo nicotine metabolism. Pharmacogenet Genomics 28:7-16
Monteiro, Maria B; Ramm, Susanne; Chandrasekaran, Vidya et al. (2018) A High-Throughput Screen Identifies DYRK1A Inhibitor ID-8 that Stimulates Human Kidney Tubular Epithelial Cell Proliferation. J Am Soc Nephrol 29:2820-2833
Miller, Kristin A; Spalt, Elizabeth W; Gassett, Amanda J et al. (2018) Estimating ambient-origin PM2.5 exposure for epidemiology: observations, prediction, and validation using personal sampling in the Multi-Ethnic Study of Atherosclerosis. J Expo Sci Environ Epidemiol :
Wallace, James C; Youngblood, Jessica E; Port, Jesse A et al. (2018) Variability in metagenomic samples from the Puget Sound: Relationship to temporal and anthropogenic impacts. PLoS One 13:e0192412
Suter, Megan K; Karr, Catherine J; John-Stewart, Grace C et al. (2018) Implications of Combined Exposure to Household Air Pollution and HIV on Neurocognition in Children. Int J Environ Res Public Health 15:
Hooper, Laura G; Kaufman, Joel D (2018) Ambient Air Pollution and Clinical Implications for Susceptible Populations. Ann Am Thorac Soc 15:S64-S68
Wong, Timothy; Wang, Zhican; Chapron, Brian D et al. (2018) Polymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D3-3-O-Sulfate, a Major Circulating Vitamin D Metabolite in Humans. Drug Metab Dispos 46:367-379
Riley, Erin A; Carpenter, Emily E; Ramsay, Joemy et al. (2018) Evaluation of 1-Nitropyrene as a Surrogate Measure for Diesel Exhaust. Ann Work Expo Health 62:339-350
Cheng, Sunny Lihua; Li, Xueshu; Lehmler, Hans-Joachim et al. (2018) Gut Microbiota Modulates Interactions Between Polychlorinated Biphenyls and Bile Acid Homeostasis. Toxicol Sci 166:269-287

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