Overall Objectives and Specific Aims The purpose of the Analytical Instrumentation Facility Core is to support Center investigators in the detection, characterization, and quantification of chemicals and biomolecules.
The specific aims of Facility Core 2 are: 1. To provide sensitive protein identification and modification analyses; 2. To offer services for the identification and quantification of metabolites, nutrients, xenobiotics, and various types of macromolecular damage; 3. To implement novel analytical methods and improve the sensitivity and throughput of existing analyses; 4. To provide consultation on the selection and implementation of analytical methods and training opportunities in usage and applications of analytical instrumentation; 5. To develop tissue and biofluid analytical assays relevant to translational research in coordination with the Integrated Health Sciences Facility Core; 6. To foster partnerships for improved access to high end analytical instrumentation and technical expertise in support of Center research. The Analytical Facility Core will provide sophisticated mass spectrometry resources and expertise to support Center Investigator research efforts. It will neither unnecessarily duplicate analytical capabilities of investigators'laboratories nor become a processing center for large numbers of routine analyses. The goals of the Core have changed slightly during the past funding period to reflect developments in the fields of proteomics, metabolomics and biomarker identification, and the increased interest in these new technologies by Center Members. Acquisition of major new instrumentation has enabled significant improvements in existing services as well as expansion into novel assays applied to protein, drug and metabolite analyses. The facility has worked in close cooperation with the Molecular Biology Facility Core to integrate services required for protein expression profiling projects and analysis of serum samples. We anticipate a similar degree of cooperation with the proposed Integrative Health Science Facility Core which will utilize assays developed for analysis of tissue and biofluid samples to investigate the role of environmental factors in human disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES007784-14
Application #
8055911
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
2010-04-01
Budget End
2011-03-31
Support Year
14
Fiscal Year
2010
Total Cost
$239,306
Indirect Cost
Name
University of Texas MD Anderson Cancer Center
Department
Type
DUNS #
800772139
City
Houston
State
TX
Country
United States
Zip Code
77030
Han, Ying; Rand, Kristin A; Hazelett, Dennis J et al. (2016) Prostate Cancer Susceptibility in Men of African Ancestry at 8q24. J Natl Cancer Inst 108:
Rand, Kristin A; Rohland, Nadin; Tandon, Arti et al. (2016) Whole-exome sequencing of over 4100 men of African ancestry and prostate cancer risk. Hum Mol Genet 25:371-81
Rand, Kristin A; Song, Chi; Dean, Eric et al. (2016) A Meta-analysis of Multiple Myeloma Risk Regions in African and European Ancestry Populations Identifies Putatively Functional Loci. Cancer Epidemiol Biomarkers Prev 25:1609-1618
Rao, Dharanija; Macias, Everardo; Carbajal, Steve et al. (2015) Constitutive Stat3 activation alters behavior of hair follicle stem and progenitor cell populations. Mol Carcinog 54:121-33
Han, Ying; Signorello, Lisa B; Strom, Sara S et al. (2015) Generalizability of established prostate cancer risk variants in men of African ancestry. Int J Cancer 136:1210-7
Takata, Kei-Ichi; Tomida, Junya; Reh, Shelley et al. (2015) Conserved overlapping gene arrangement, restricted expression, and biochemical activities of DNA polymerase ? (POLN). J Biol Chem 290:24278-93
Han, Ying; Hazelett, Dennis J; Wiklund, Fredrik et al. (2015) Integration of multiethnic fine-mapping and genomic annotation to prioritize candidate functional SNPs at prostate cancer susceptibility regions. Hum Mol Genet 24:5603-18
Nowinski, Sara M; Solmonson, Ashley; Rundhaug, Joyce E et al. (2015) Mitochondrial uncoupling links lipid catabolism to Akt inhibition and resistance to tumorigenesis. Nat Commun 6:8137
Cifarelli, V; Hursting, S D (2015) Obesity, Diabetes and Cancer: A Mechanistic Perspective. Int J Diabetol Vasc Dis Res 2015:
Perez, Carlos J; Rundhaug, Joyce E; Johnson, David G et al. (2014) Slug expression in mouse skin and skin tumors is not regulated by p53. J Invest Dermatol 134:566-568

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