Abstract

The principal objective of the Biomarkers Facilities Core is to provide facilities and expertise to generate highly specific and ultra sensitive measurements of selected biomarkers for funded and proposed new research by members of the NIEHS Center. The biomarkers to be measured include assays of DNA and protein adducts, abasic sites in DNA, oxidative stress, and GSH, as well as methods for immunoaffinity chromatography and immunohistochemistry. Such assays are critical for assessing specific hypotheses regarding basic mechanisms of carcinogenesis and other diseases, the roles of causal agents and covariates (e.g., nutrition), bioactivation and detoxication, DNA repair and biomarkers of exposure in occupational and environmental epidemiology. By providing this newest technology, the Biomarkers Core will provide members of the NIEHS Center a major opportunity for ground breaking studies.
The aims of the Core are to: 1) to make available to Center members state of the art assays for biomarkers of cancer and other diseases; 2) to assist Center members with experimental design, tissue collection and assays of various biomarkers; and, 3) to foster applications of biomarkers in pilot projects and new collaborative research projects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
1P30ES010126-01A1
Application #
6458278
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
2001-04-01
Project End
2005-03-31
Budget Start
Budget End
Support Year
1
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Mayne, Stephanie L; Auchincloss, Amy H; Tabb, Loni Philip et al. (2018) Associations of Bar and Restaurant Smoking Bans With Smoking Behavior in the CARDIA Study: A 25-Year Study. Am J Epidemiol 187:1250-1258
Oliver-Williams, Clare; Howard, Annie Green; Navas-Acien, Ana et al. (2018) Cadmium body burden, hypertension, and changes in blood pressure over time: results from a prospective cohort study in American Indians. J Am Soc Hypertens 12:426-437.e9
Pace, Nelson D; Desrosiers, Tania A; Carmichael, Suzan L et al. (2018) Antioxidant Consumption is Associated with Decreased Odds of Congenital Limb Deficiencies. Paediatr Perinat Epidemiol 32:90-99
Gray, Kathleen M (2018) From Content Knowledge to Community Change: A Review of Representations of Environmental Health Literacy. Int J Environ Res Public Health 15:
Orlow, Irene; Shi, Yang; Kanetsky, Peter A et al. (2018) The interaction between vitamin D receptor polymorphisms and sun exposure around time of diagnosis influences melanoma survival. Pigment Cell Melanoma Res 31:287-296
Zheng, Xiaojing; O'Connell, Catherine M; Zhong, Wujuan et al. (2018) Discovery of Blood Transcriptional Endotypes in Women with Pelvic Inflammatory Disease. J Immunol 200:2941-2956
Tappata, Manaswita; Eluri, Swathi; Perjar, Irina et al. (2018) Association of mast cells with clinical, endoscopic, and histologic findings in adults with eosinophilic esophagitis. Allergy 73:2088-2092
Herceg, Zdenko; Ghantous, Akram; Wild, Christopher P et al. (2018) Roadmap for investigating epigenome deregulation and environmental origins of cancer. Int J Cancer 142:874-882
Hoffman, Kate; Stapleton, Heather M; Lorenzo, Amelia et al. (2018) Prenatal exposure to organophosphates and associations with birthweight and gestational length. Environ Int 116:248-254
Little, Michael S; Pellock, Samuel J; Walton, William G et al. (2018) Structural basis for the regulation of ?-glucuronidase expression by human gut Enterobacteriaceae. Proc Natl Acad Sci U S A 115:E152-E161

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