The Genetic Susceptibility Research Core seeks to elucidate the relative contributions of genetic variants to human risk of environmental disease. There are two broad areas of research into how genes affect the occurrence of environmental disease. One is primarily epidemiologic in approach, using association studies to link the incidence of disease with a particular genetic polymorphism or set of polymorphisms. A second research pathway studies familial cancer genes, which have been identified primarily by genetic linkage analyses. These two approaches thus integrate the efforts of epidemiological scientists with those of molecular biological-based investigators in the evaluation of how changes in cell cycle check points and DNA repair mechanisms can lead to disease phenotypes, particularly those involving various cancers. The Core has five objectives. The first is to support and expand collaborative research in genetic susceptibility utilizing state-of-the-art laboratory methods and rigorously designed epidemiologic approaches. The second is to integrate, on a regular basis, researchers in mechanisms of DNA damage and repair and epidemiologists involved in field studies of gene/environment interactions in carcinogenesis. The third is to promote the integration of molecular genetics into the areas of reproductive, pediatric, pulmonary, and cardiovascular disease research. The fourth is to foster dialogue regarding policy implications of genetic-testing technology and results of genetic research. The final objective is to stimulate new collaborations through pilot projects.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES010126-09
Application #
7799328
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
2009-04-01
Budget End
2010-03-31
Support Year
9
Fiscal Year
2009
Total Cost
$28,521
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
van Bömmel, Alena; Love, Michael I; Chung, Ho-Ryun et al. (2018) coTRaCTE predicts co-occurring transcription factors within cell-type specific enhancers. PLoS Comput Biol 14:e1006372
McNeill, Robert S; Stroobant, Emily E; Smithberger, Erin et al. (2018) PIK3CA missense mutations promote glioblastoma pathogenesis, but do not enhance targeted PI3K inhibition. PLoS One 13:e0200014
Daniels, Julie L (2018) Considerations for Studying Folate Beyond the Typical Range of Exposure. Paediatr Perinat Epidemiol 32:112-113
Reidel, Boris; Radicioni, Giorgia; Clapp, Phillip W et al. (2018) E-Cigarette Use Causes a Unique Innate Immune Response in the Lung, Involving Increased Neutrophilic Activation and Altered Mucin Secretion. Am J Respir Crit Care Med 197:492-501
Tennyson, Robert L; Gettler, Lee T; Kuzawa, Christopher W et al. (2018) Lifetime socioeconomic status and early life microbial environments predict adult blood telomere length in the Philippines. Am J Hum Biol 30:e23145
Thomas, Nancy E; Edmiston, Sharon N; Orlow, Irene et al. (2018) Inherited Genetic Variants Associated with Melanoma BRAF/NRAS Subtypes. J Invest Dermatol 138:2398-2404
Porrello, Alessandro; Leslie, Patrick L; Harrison, Emily B et al. (2018) Factor XIIIA-expressing inflammatory monocytes promote lung squamous cancer through fibrin cross-linking. Nat Commun 9:1988
Manuck, Tracy A; Smeester, Lisa; Martin, Elizabeth M et al. (2018) Epigenetic Regulation of the Nitric Oxide Pathway, 17-? Hydroxyprogesterone Caproate, and Recurrent Preterm Birth. Am J Perinatol 35:721-728
Barrington, William T; Wulfridge, Phillip; Wells, Ann E et al. (2018) Improving Metabolic Health Through Precision Dietetics in Mice. Genetics 208:399-417
Cui, Tianqu; Zeng, Zhexi; Dos Santos, Erickson O et al. (2018) Development of a hydrophilic interaction liquid chromatography (HILIC) method for the chemical characterization of water-soluble isoprene epoxydiol (IEPOX)-derived secondary organic aerosol. Environ Sci Process Impacts 20:1524-1536

Showing the most recent 10 out of 1900 publications