The primary mission of the Integrative Health Sciences Facility Core (IHSFC) is to support CEHS investigators who conduct research using human study participants. IHSFC addresses four broad areas of interest. First, the IHSFC provides scientific consultation for clinical and population-based studies. These services promote collaborations and enhance scientific productivity. Second, biospecimen processing and genotyping sub-core laboratories provide platforms for short-term pilot projects and long-term epidemiologic studies for Center members. These sub-core laboratories provide access to state of the art equipment and a high level of quality control and maximal throughput that could not be achieved by individual investigators. The genotyping sub-core also provides typing of laboratory rodent strains in order to promote cross-disciplinary collaborations in functional and comparative genomics for Center members. Third, the IHSFC provides expertise in spatial analysis and geographic information systems, in order to integrate human epidemiologic studies with environmental exposure measurement. Fourth, the IHSFC serves as a liaison to a variety of core laboratories, resources and facilities at UNC that are of use to specific CEHS investigators. The IHSFC is closely integrated with the Biostatistics and Bioinformatics Facility Core (BBFC) and the Systems Biology Facility Core (SBFC) through the Research Navigator and the Flexible Interdisciplinary Research Groups (FIRG).

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
2P30ES010126-10
Application #
7903025
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
2010-08-15
Budget End
2011-03-31
Support Year
10
Fiscal Year
2010
Total Cost
$132,263
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
van Bömmel, Alena; Love, Michael I; Chung, Ho-Ryun et al. (2018) coTRaCTE predicts co-occurring transcription factors within cell-type specific enhancers. PLoS Comput Biol 14:e1006372
McNeill, Robert S; Stroobant, Emily E; Smithberger, Erin et al. (2018) PIK3CA missense mutations promote glioblastoma pathogenesis, but do not enhance targeted PI3K inhibition. PLoS One 13:e0200014
Daniels, Julie L (2018) Considerations for Studying Folate Beyond the Typical Range of Exposure. Paediatr Perinat Epidemiol 32:112-113
Reidel, Boris; Radicioni, Giorgia; Clapp, Phillip W et al. (2018) E-Cigarette Use Causes a Unique Innate Immune Response in the Lung, Involving Increased Neutrophilic Activation and Altered Mucin Secretion. Am J Respir Crit Care Med 197:492-501
Tennyson, Robert L; Gettler, Lee T; Kuzawa, Christopher W et al. (2018) Lifetime socioeconomic status and early life microbial environments predict adult blood telomere length in the Philippines. Am J Hum Biol 30:e23145
Thomas, Nancy E; Edmiston, Sharon N; Orlow, Irene et al. (2018) Inherited Genetic Variants Associated with Melanoma BRAF/NRAS Subtypes. J Invest Dermatol 138:2398-2404
Porrello, Alessandro; Leslie, Patrick L; Harrison, Emily B et al. (2018) Factor XIIIA-expressing inflammatory monocytes promote lung squamous cancer through fibrin cross-linking. Nat Commun 9:1988
Manuck, Tracy A; Smeester, Lisa; Martin, Elizabeth M et al. (2018) Epigenetic Regulation of the Nitric Oxide Pathway, 17-? Hydroxyprogesterone Caproate, and Recurrent Preterm Birth. Am J Perinatol 35:721-728
Barrington, William T; Wulfridge, Phillip; Wells, Ann E et al. (2018) Improving Metabolic Health Through Precision Dietetics in Mice. Genetics 208:399-417
Cui, Tianqu; Zeng, Zhexi; Dos Santos, Erickson O et al. (2018) Development of a hydrophilic interaction liquid chromatography (HILIC) method for the chemical characterization of water-soluble isoprene epoxydiol (IEPOX)-derived secondary organic aerosol. Environ Sci Process Impacts 20:1524-1536

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