Situated in the heart of Detroit, the Wayne State University """"""""Center for Urban Responses to Environmental Stressors"""""""" (CURES) is focused on understanding how exposures to stressors that are prevalent in the urban industrialized environment, both chemical and non-chemical, impact human health. Special emphasis is placed on life windows of heightened susceptibility to environmental exposure and vulnerable persons at risk for environmental disease (e.g., children and adults of low socio-economic status, older adults, immigrants, refugees, and first responders). The hypothesis of the CURES Center is that diseases that compromise the quality of life in an industrialized urban environment, such as Detroit, occur as a consequence of dynamic interactions among an individual's genetic and epigenetic make-up, nutritional status, and environmental stressors, which include chronic low-level toxicant exposures as well as psychosocial and physical stressors, that re-program key cellular regulatory networks to favor pathogenesis. Four disease-oriented research interest groups serve as interdisciplinary hubs for population and basic scientists and community members interested in the role of environmental exposure in (1) immune disorders, (2) metabolic disease, (3) cancer, and (4) mental health disturbances. The Transdisciplinary/Translational Integration team (TRANSIT) works with community advisors to apply an integrated transdisciplinary approach to solving environmental health problems. The Integrative Health Sciences Facility Core guides Center researchers transitioning toward translational research studies and provides stem cell and human biospecimen services. The Exposure Signatures Facility Core enables Center members to apply integrated, state-of-the-art genomic, epigenomic, proteomic, and bioinformatic strategies to environmental health science research. The Community Outreach and Engagement Core provides for bi-directional exchange between the urban community at risk for environmental illness and Center members. CURES also sponsors programs focused on career and new project development. The CURES Center is a dynamic transdisciplinary research team that is dedicated to environmental disease prevention and creating a cleaner and healthier living and working environment in the city of Detroit.

Public Health Relevance

The Wayne State University (WSU) Center for Urban Responses to Environmental Stressors (CURES) is focused on establishing a cleaner and healthier living and working environment in the city of Detroit. The CURES Center applies an integrated team approach to understand how exposure to urban environmental chemical and non-chemical stressors affects human health.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
1P30ES020957-01A1
Application #
8619368
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
2014-06-05
Project End
2017-03-31
Budget Start
2014-06-05
Budget End
2015-03-31
Support Year
1
Fiscal Year
2014
Total Cost
$181,731
Indirect Cost
$62,171
Name
Wayne State University
Department
Type
DUNS #
001962224
City
Detroit
State
MI
Country
United States
Zip Code
48202
Alford, Sharon Hensley; Divine, George; Chao, Chun et al. (2018) Serum cholesterol trajectories in the 10 years prior to lymphoma diagnosis. Cancer Causes Control 29:143-156
Ghosh, Santu; Tiwari, Ram C; Ghosh, Samiran (2018) Bayesian approach for assessing noninferiority in a three-arm trial with binary endpoint. Pharm Stat 17:342-357
Marshall, Narcis A; Marusak, Hilary A; Sala-Hamrick, Kelsey J et al. (2018) Socioeconomic disadvantage and altered corticostriatal circuitry in urban youth. Hum Brain Mapp 39:1982-1994
Gawdzik, Joseph C; Yue, Monica S; Martin, Nathan R et al. (2018) sox9b is required in cardiomyocytes for cardiac morphogenesis and function. Sci Rep 8:13906
Ramseyer, Vanesa D; Kimler, Victoria A; Granneman, James G (2018) Vacuolar protein sorting 13C is a novel lipid droplet protein that inhibits lipolysis in brown adipocytes. Mol Metab 7:57-70
Thomason, Moriah E (2018) Structured Spontaneity: Building Circuits in the Human Prenatal Brain. Trends Neurosci 41:1-3
Thakur, Chitra; Chen, Bailing; Li, Lingzhi et al. (2018) Loss of mdig expression enhances DNA and histone methylation and metastasis of aggressive breast cancer. Signal Transduct Target Ther 3:25
Mitrea, Cristina; Wijesinghe, Priyanga; Dyson, Greg et al. (2018) Integrating 5hmC and gene expression data to infer regulatory mechanisms. Bioinformatics 34:1441-1447
Cassidy-Bushrow, A E; Burmeister, C; Havstad, S et al. (2018) Prenatal antimicrobial use and early-childhood body mass index. Int J Obes (Lond) 42:1-7
Meyer, Danielle N; Baker, Bridget B; Baker, Tracie R (2018) Ancestral TCDD Exposure Induces Multigenerational Histologic and Transcriptomic Alterations in Gonads of Male Zebrafish. Toxicol Sci 164:603-612

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