The central theme of the University of California Davis Center Environmental Exposures, Mechanisms, and the Development of Disease is the identification of exposure pathways and disease mechanisms in order to deepen understanding of how environmental exposures threaten human health and to develop strategies to mitigate their effects. This Center brings together faculty from 19 departments in four schools and colleges engaged in environmental health sciences (EHS) research spanning molecular mechanisms, exposure science, pathophysiology, and epidemiology, with relevance to human conditions. The Center will markedly expand UC Davis EHS research at UC Davis by: 1) advancing cutting-edge science, 2) enlarging the cadre of EHS researchers, and 3) engaging with policy-makers, advocacy organizations and health professionals, to ensure relevance of our research and to translate findings into public health improvement. This EHS Core Center will build upon a critical mass of faculty independently funded in EHS, facilitate synergistic collaborations and generate novel scientific breakthroughs unlikely to occur without the opportunities for interaction and integratio this Center will provide. The Center will train young investigators and attract faculty previously not working in EHS who bring their skills and technologies to EHS research. Building on the major EHS strengths, the four primary thematic areas are: environmentally-induced effects on 1) nervous system, 2) respiratory, 3) immune, and 4) endocrine or metabolic function. Exposures of interest include an array of particles and volatile organic contaminant compounds in ambient air, and pollutants in drinking water, in food and from household or personal care products. Center leadership will solicit input from an External Science Advisory Committee, an Internal Executive Advisory Committee, and a Community Stakeholder Advisory Committee. The organizational structure includes an Administrative Core, a Career Development Program, a Pilot Projects Program, an Exposure Core, an Integrative Health Sciences Core, and a Community Outreach and Engagement Core.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Center Core Grants (P30)
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Special Emphasis Panel (EHS (P3))
Program Officer
Thompson, Claudia L
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University of California Davis
Public Health & Prev Medicine
Schools of Medicine
United States
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Keil, Kimberly P; Miller, Galen W; Chen, Hao et al. (2018) PCB 95 promotes dendritic growth in primary rat hippocampal neurons via mTOR-dependent mechanisms. Arch Toxicol 92:3163-3173
Bever, Candace S; Rand, Amy A; Nording, Malin et al. (2018) Effects of triclosan in breast milk on the infant fecal microbiome. Chemosphere 203:467-473
La Merrill, M A; Lind, P M; Salihovic, S et al. (2018) The association between p,p'-DDE levels and left ventricular mass is mainly mediated by obesity. Environ Res 160:541-546
Kerin, Tara; Volk, Heather; Li, Weiyan et al. (2018) Association Between Air Pollution Exposure, Cognitive and Adaptive Function, and ASD Severity Among Children with Autism Spectrum Disorder. J Autism Dev Disord 48:137-150
Miller, Galen W; Chandrasekaran, Vidya; Yaghoobi, Bianca et al. (2018) Opportunities and challenges for using the zebrafish to study neuronal connectivity as an endpoint of developmental neurotoxicity. Neurotoxicology 67:102-111
Smit-McBride, Zeljka; Nguyen, Johnny; Elliott, Garrett W et al. (2018) Effects of aging and environmental tobacco smoke exposure on ocular and plasma circulatory microRNAs in the Rhesus macaque. Mol Vis 24:633-646
Albrengues, Jean; Shields, Mario A; Ng, David et al. (2018) Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice. Science 361:
Sethi, Sunjay; Keil, Kimberly P; Lein, Pamela J (2018) 3,3'-Dichlorobiphenyl (PCB 11) promotes dendritic arborization in primary rat cortical neurons via a CREB-dependent mechanism. Arch Toxicol 92:3337-3345
Stamou, Marianna; Grodzki, Ana Cristina; van Oostrum, Marc et al. (2018) Fc gamma receptors are expressed in the developing rat brain and activate downstream signaling molecules upon cross-linking with immune complex. J Neuroinflammation 15:7
Zamuruyev, Konstantin O; Borras, Eva; Pettit, Dayna R et al. (2018) Effect of temperature control on the metabolite content in exhaled breath condensate. Anal Chim Acta 1006:49-60

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