The Icahn School of Medicine at Mount Sinai seeks to form a new Environmental Health Sciences Core Center-the Mount Sinai Transdisciplinary Center on Health Effects of Early Environmental Exposures. Our Center will leverage Mount Sinai's remarkable recent growth and build on our nationally and internationally recognized programs in children's environmental health. Our Center's mission is to understand how environmental exposures in early life influence health, development, and risk of disease and dysfunction across the life span - in infancy, childhood, adolescence and beyond. We will study the health impacts of chemical, genetic, nutritional, and social exposures and the interactions among them. Our approach will be transdisciplinary and highly translational. We will combine clinical, population-based and biological research with leading-edge genetics, epigenetics, and bioinformatics in the setting of a hospital-based, urban school of medicine. Through our clinical and community partnerships, we will translate our research findings into evidence-based approaches for disease prevention and treatment. To focus our research, our Center will establish three Research Groups: Endocrine and Metabolic Disruption, Neuro-Immunomodulation, and Oxidant-Antioxidant Imbalance. These Research Groups will bring together basic scientists, clinicians and population scientists committed to developing new, transdisciplinary research in environmental health The Research Groups will be supported by three Facility Cores: an Integrated Health Sciences Facility Core with Subcores in Exposure Biomarkers, Molecular Biomarkers, Clinical Population Access, and a Placenta Biobank; an Environmental Epidemiology, Statistics and Informatics Facility Core; and a clinically-oriented Phenotyping and Stress Assessment Facility Core. The Center supports a Pilot Projects Program, a Career Development Program, and a Community Outreach and Engagement Core, committed to bidirectional communication and partnership with the diverse and disadvantaged communities that Mount Sinai serves. Mount Sinai has attracted well-funded senior faculty who will be leaders in our Center, built a strong base of NIEHS funding, constructed new laboratories, assembled multiple prospective birth cohorts, developed a successful research training fellowship in pediatric environmental health, developed a robust Pilot Projects Program, gained designation as a WHO Collaborating Centre, and made significant scientific discoveries. Formation of an NIEHS Core Center will strengthen our program identity, sustain our scientific capacity, and help us build the careers of the young scientists who are our future leaders.
The Mount Sinai Transdisciplinary Center on Health Effects of Early Environmental Exposures will advance public health in the United States and around the world by (1) supporting state-of-the-art research that is designed to discover the environmental causes of disease and disability in children, (2) translating scientific discoveries into new, evidence-based strategies for disease prevention and treatment, and (3) building the careers of young physicians and scientists who will be our nation's future public health leaders.
|de Water, Erik; Proal, Erika; Wang, Victoria et al. (2018) Prenatal manganese exposure and intrinsic functional connectivity of emotional brain areas in children. Neurotoxicology 64:85-93|
|Butler, Lindsey; Gennings, Chris; Peli, Marco et al. (2018) Assessing the contributions of metals in environmental media to exposure biomarkers in a region of ferroalloy industry. J Expo Sci Environ Epidemiol :|
|Shameer, Khader; Glicksberg, Benjamin S; Hodos, Rachel et al. (2018) Systematic analyses of drugs and disease indications in RepurposeDB reveal pharmacological, biological and epidemiological factors influencing drug repositioning. Brief Bioinform 19:656-678|
|Deyssenroth, Maya A; Gennings, Chris; Liu, Shelley H et al. (2018) Intrauterine multi-metal exposure is associated with reduced fetal growth through modulation of the placental gene network. Environ Int 120:373-381|
|Lee, Alison G; Le Grand, Blake; Hsu, Hsiao-Hsien Leon et al. (2018) Prenatal fine particulate exposure associated with reduced childhood lung function and nasal epithelia GSTP1 hypermethylation: Sex-specific effects. Respir Res 19:76|
|Morris-Schaffer, Keith; Sobolewski, Marissa; Allen, Joshua L et al. (2018) Effect of neonatal hyperoxia followed by concentrated ambient ultrafine particle exposure on cumulative learning in C57Bl/6J mice. Neurotoxicology 67:234-244|
|Rosa-Parra, Jose A; Tamayo-Ortiz, Marcela; Lamadrid-Figueroa, Hector et al. (2018) Diurnal Cortisol Concentrations and Growth Indexes of 12- to 48-Month-Old Children From Mexico City. J Clin Endocrinol Metab 103:3386-3393|
|Sanders, Alison P; Saland, Jeffrey M; Wright, Robert O et al. (2018) Perinatal and childhood exposure to environmental chemicals and blood pressure in children: a review of literature 2007-2017. Pediatr Res 84:165-180|
|Buckley, Jessie P; Quirós-Alcalá, Lesliam; Teitelbaum, Susan L et al. (2018) Associations of prenatal environmental phenol and phthalate biomarkers with respiratory and allergic diseases among children aged 6 and 7?years. Environ Int 115:79-88|
|Liu, Shelley H; Bobb, Jennifer F; Lee, Kyu Ha et al. (2018) Lagged kernel machine regression for identifying time windows of susceptibility to exposures of complex mixtures. Biostatistics 19:325-341|
Showing the most recent 10 out of 289 publications