Abstract

The objectives of the Vision Research Center grant are: (1) to increase knowledge concerning normal vision; (2) to apply this knowledge to the preservation and restoration of human vision. To achieve these overall scientific goals, a multidisciplinary research program has been developed. Related to the eye and vision, this program consists of the following major basic science and clinical research components: Molecular Biology, Biophysics, Electrophysiology, Microbiology and Immunology, Ophthalmic Pathology, Ophthalmology--Retina and Lens Disease Research, Pediatric Ophthalmology Research and Vision-Related Genetic Disorders. Appropriately interrelated, the major components of this program apply a wide spectrum of laboratory and clinical methods of investigAtion to an extensive array of research projects. Support is requested for the following Core modules: Biochemistry, Pathology, Electron Microscopy, Machine Shop, Clinical Investigation, and Administration.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY000331-24
Application #
3102393
Study Section
Vision Research and Training Committee (VSN)
Project Start
1978-11-01
Project End
1994-02-28
Budget Start
1990-03-01
Budget End
1991-02-28
Support Year
24
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Kintzer, Alexander F; Green, Evan M; Dominik, Pawel K et al. (2018) Structural basis for activation of voltage sensor domains in an ion channel TPC1. Proc Natl Acad Sci U S A 115:E9095-E9104
Bergdoll, Lucie A; Lerch, Michael T; Patrick, John W et al. (2018) Protonation state of glutamate 73 regulates the formation of a specific dimeric association of mVDAC1. Proc Natl Acad Sci U S A 115:E172-E179
Vahedi, Farnoosh; Chung, Doug D; Gee, Katherine M et al. (2018) Epithelial Recurrent Erosion Dystrophy Secondary to COL17A1 c.3156C>T Mutation in a Non-white Family. Cornea 37:909-911
Zhang, Xiang-Mei; Hashimoto, Takao; Tang, Ronald et al. (2018) Elevated expression of human bHLH factor ATOH7 accelerates cell cycle progression of progenitors and enhances production of avian retinal ganglion cells. Sci Rep 8:6823
Chaudhuri, Zia; Demer, Joseph L (2018) Long-term Surgical Outcomes in the Sagging Eye Syndrome. Strabismus 26:6-10
Esteve-Rudd, Julian; Hazim, Roni A; Diemer, Tanja et al. (2018) Defective phagosome motility and degradation in cell nonautonomous RPE pathogenesis of a dominant macular degeneration. Proc Natl Acad Sci U S A 115:5468-5473
Morshedian, Ala; Woodruff, Michael L; Fain, Gordon L (2018) Role of recoverin in rod photoreceptor light adaptation. J Physiol 596:1513-1526
Glasgow, Ben J; Abduragimov, Adil R (2018) Interaction of ceramides and tear lipocalin. Biochim Biophys Acta Mol Cell Biol Lipids 1863:399-408
Demer, Joseph L (2018) Knobby Eye Syndrome. Strabismus 26:33-41
Glasgow, Ben J; Abduragimov, Adil R (2018) Ligand binding studies by high speed centrifugal precipitation and linear spectral summation using ultraviolet-visible absorption spectroscopy. MethodsX 5:345-351

Showing the most recent 10 out of 289 publications