The Vision Research Division of the Jules Stein Eye Institute (JSEI) and affiliated Departments at UCLA consists of 15 vision scientists with NEI funding. The objective of the Core Grant for Vision Research at the JSEI is to provide a critically needed infrastructure to support the research activities of this talented group of scientists whose common goal is to increase basic knowledge of the visual system and its disorders. To achieve this objective, personnel and instrument support facilities are organized according to the following modules: (1) Biochemistry and Molecular Biology Instrumentation; (2) Microscopy and Imaging; (3) Machine Shop and (4) Live imaging and Functional Evaluation. These Modules provide instrumentation commonly used by multiple laboratories and are essential to the success of on-going projects as well as to enable new collaborative efforts. Purchase of state-of-the-art instruments in the modules was made possible by the generosity of the JSEI through various donors as well as recent funds from the American Recovery and Reinvestment Act. Support in the form of the Core grant is requested to maintain these Modules through instrument service contracts, and to provide necessary personnel support to assist and train users and provide routine maintenance.

Public Health Relevance

The overall goals of the Vision Science Investigators at the Jules Stein Eye Institute are to: (1) determine molecular mechanisms of visual function; (2) use that basic knowledge to understand the disease states that arise from defects (mutations) in specific proteins, and (3) explore genetic and pharmacological means of correcting these defects. Success in these endeavors will have a hriajor impact in improving vision health.

National Institute of Health (NIH)
National Eye Institute (NEI)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZEY1)
Program Officer
Liberman, Ellen S
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Los Angeles
Schools of Medicine
Los Angeles
United States
Zip Code
Esteve-Rudd, Julian; Hazim, Roni A; Diemer, Tanja et al. (2018) Defective phagosome motility and degradation in cell nonautonomous RPE pathogenesis of a dominant macular degeneration. Proc Natl Acad Sci U S A 115:5468-5473
Morshedian, Ala; Woodruff, Michael L; Fain, Gordon L (2018) Role of recoverin in rod photoreceptor light adaptation. J Physiol 596:1513-1526
Glasgow, Ben J; Abduragimov, Adil R (2018) Interaction of ceramides and tear lipocalin. Biochim Biophys Acta Mol Cell Biol Lipids 1863:399-408
Demer, Joseph L (2018) Knobby Eye Syndrome. Strabismus 26:33-41
Glasgow, Ben J; Abduragimov, Adil R (2018) Ligand binding studies by high speed centrifugal precipitation and linear spectral summation using ultraviolet-visible absorption spectroscopy. MethodsX 5:345-351
Hazim, Roni A; Volland, Stefanie; Yen, Alice et al. (2018) Rapid differentiation of the human RPE cell line, ARPE-19, induced by nicotinamide. Exp Eye Res 179:18-24
Glasgow, Ben J; Abduragimov, Adil R (2018) Data on Orphan tear lipid analogs, synthesis and binding to tear lipocalin. Data Brief 18:999-1004
Sarria, Ignacio; Cao, Yan; Wang, Yuchen et al. (2018) LRIT1 Modulates Adaptive Changes in Synaptic Communication of Cone Photoreceptors. Cell Rep 22:3562-3573
Peng, Yingqian; Baulier, Edouard; Ke, Yifeng et al. (2018) Human embryonic stem cells extracellular vesicles and their effects on immortalized human retinal Müller cells. PLoS One 13:e0194004
Clark, Robert A; Demer, Joseph L (2018) The Globe's Eccentric Rotational Axis: Why Medial Rectus Surgery Is More Potent than Lateral Rectus Surgery. Ophthalmology 125:1234-1238

Showing the most recent 10 out of 289 publications