14 investigators from the Center for Visual Science (CVS) at the University of Rochester will participate in the Core Grant. These investigators have primary appointments in five departments: Brain and Cognitive Sciences, Computer Science, Neurobiology and Anatomy, Neurology, and Ophthalmology. They are bound together by research interests in three domains: 1) the relationship between visual experience and its neural substrate, 2) the role of vision in guiding behavior, and 3)mechanisms of retinal disease. The proposed Core will provide three modules, each of which will benefit all three of these research domains: 1) A computing Module that will provide expertise in the generation of complex visual stimuli for psychophysical and physiological experiments, real-time experimental control, data analysis, and modelling. 2) An Instrumental Module that will provide expertise in optical, electronic, and mechanical engineering to design and assemble novel instrumentation such as that required for eye, head, and hand tracking, multielectrode recording in primate cortex, and high resolution fundus imaging. 3) A new Histology Module that will provide a shared, staffed facility equipped to process both ocular and brain tissue.
| Cheong, Soon Keen; Strazzeri, Jennifer M; Williams, David R et al. (2018) All-optical recording and stimulation of retinal neurons in vivo in retinal degeneration mice. PLoS One 13:e0194947 |
| Granger, Charles E; Yang, Qiang; Song, Hongxin et al. (2018) Human Retinal Pigment Epithelium: In Vivo Cell Morphometry, Multispectral Autofluorescence, and Relationship to Cone Mosaic. Invest Ophthalmol Vis Sci 59:5705-5716 |
| Cheong, Soon K; Xiong, Wenjun; Strazzeri, Jennifer M et al. (2018) In Vivo Functional Imaging of Retinal Neurons Using Red and Green Fluorescent Calcium Indicators. Adv Exp Med Biol 1074:135-144 |
| Zinszer, Benjamin D; Bayet, Laurie; Emberson, Lauren L et al. (2018) Decoding semantic representations from functional near-infrared spectroscopy signals. Neurophotonics 5:011003 |
| McGregor, Juliette E; Yin, Lu; Yang, Qiang et al. (2018) Functional architecture of the foveola revealed in the living primate. PLoS One 13:e0207102 |
| Lockwood, Colin T; Vaughn, William; Duffy, Charles J (2018) Attentional ERPs distinguish aging and early Alzheimer's dementia. Neurobiol Aging 70:51-58 |
| Chernoff, Benjamin L; Teghipco, Alex; Garcea, Frank E et al. (2018) A Role for the Frontal Aslant Tract in Speech Planning: A Neurosurgical Case Study. J Cogn Neurosci 30:752-769 |
| Alarcon-Martinez, Luis; Yilmaz-Ozcan, Sinem; Yemisci, Muge et al. (2018) Capillary pericytes express ?-smooth muscle actin, which requires prevention of filamentous-actin depolymerization for detection. Elife 7: |
| Jeon, Kye-Im; Hindman, Holly B; Bubel, Tracy et al. (2018) Corneal myofibroblasts inhibit regenerating nerves during wound healing. Sci Rep 8:12945 |
| Weiss, Menachem Y; Kuriyan, Ajay E (2018) Acute Monocular Vision Loss in a Young Adult. JAMA Ophthalmol 136:297-298 |
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